Document Detail


Generalization of habituation and intrinsic sensitization in the leech.
MedLine Citation:
PMID:  10489258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using the shortening reflex of the medicinal leech Hirudo medicinalis we examined stimulus generalization of habituation learning. Preparations received mechanosensory stimulus at two positions on the leech body wall, one site used to carry out habituation training and a second novel site to test for generalization of habituation. After training, the specific mechanosensory neurons activated by each stimulus were assessed using intracellular recordings. As expected, the closer the two sites were to each other, the greater the degree of generalization of habituation at the novel site and the more sensory cells were shared. However, a form of behavioral facilitation was observed at the trained site that resembled behavioral sensitization, but differed from the standard sensitization process in several respects. (1) Facilitation was induced by stimulation of the novel site before habituation training at the trained site, although the stimulus intensity at the novel site was equivalent to the training stimuli and was not the strong, noxious stimuli that normally induce sensitization. (2) The magnitude of the facilitating effect was proportional to the proximity of the novel and trained stimulation sites. (3) Although behavior at the trained site was facilitated, behavior at the novel site was habituated, indicating that the induced behavioral facilitation did not generalize throughout the animal, as normally occurs during sensitization, but was limited to a single stimulus-response pathway.
Authors:
B D Burrell; C L Sahley
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Learning & memory (Cold Spring Harbor, N.Y.)     Volume:  5     ISSN:  1072-0502     ISO Abbreviation:  Learn. Mem.     Publication Date:    1998 Nov-Dec
Date Detail:
Created Date:  1999-10-19     Completed Date:  1999-10-19     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  9435678     Medline TA:  Learn Mem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  405-19     Citation Subset:  IM; S    
Affiliation:
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Behavior, Animal / physiology
Electroshock
Generalization, Stimulus / physiology
Habituation, Psychophysiologic / physiology
Leeches / physiology*
Mechanoreceptors / physiology
Neurons, Afferent / physiology
Reflex / physiology
Repression-Sensitization
Grant Support
ID/Acronym/Agency:
F32-NS10065/NS/NINDS NIH HHS; R01-MH44789/MH/NIMH NIH HHS
Comments/Corrections

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