| Generality of vertebrate developmental patterns: evidence for a dermomyotome in fish. | |
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MedLine Citation:
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PMID: 16409387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The somitic compartment that gives rise to trunk muscle and dermis in amniotes is an epithelial sheet on the external surface of the somite, and is known as the dermomyotome. However, despite its central role in the development of the trunk and limbs, the evolutionary history of the dermomyotome and its role in nonamniotes is poorly understood. We have tested whether a tissue with the morphological and molecular characteristics of a dermomyotome exists in nonamniotes. We show that representatives of the agnathans and of all major clades of gnathostomes each have a layer of cells on the surface of the somite, external to the embryonic myotome. These external cells do not show any signs of terminal myogenic or dermogenic differentiation. Moreover, in the embryos of bony fishes as diverse as sturgeons (Chondrostei) and zebrafish (Teleostei) this layer of cells expresses the pax3 and pax7 genes that mark myogenic precursors. Some of the pax7-expressing cells also express the differentiation-promoting myogenic regulatory factor Myogenin and appear to enter into the myotome. We therefore suggest that the dermomyotome is an ancient and conserved structure that evolved prior to the last common ancestor of all vertebrates. The identification of a dermomyotome in fish makes it possible to apply the powerful cellular and genetic approaches available in zebrafish to the understanding of this key developmental structure. |
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Authors:
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S H Devoto; W Stoiber; C L Hammond; P Steinbacher; J R Haslett; M J F Barresi; S E Patterson; E G Adiarte; S M Hughes |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Evolution & development Volume: 8 ISSN: 1520-541X ISO Abbreviation: Evol. Dev. Publication Date: 2006 Jan-Feb |
Date Detail:
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Created Date: 2006-01-13 Completed Date: 2006-04-04 Revised Date: 2013-04-29 |
Medline Journal Info:
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Nlm Unique ID: 100883432 Medline TA: Evol Dev Country: United States |
Other Details:
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Languages: eng Pagination: 101-10 Citation Subset: IM |
Affiliation:
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Biology Department, Wesleyan University, Middletown, CT 06457, USA. sdevoto@wesleyan.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gene Expression Regulation, Developmental Paired Box Transcription Factors / genetics, metabolism Phylogeny Somites / cytology* Vertebrates / embryology*, genetics |
| Grant Support | |
ID/Acronym/Agency:
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G0300213//Medical Research Council; G0300213(65750)//Medical Research Council; G0300213(69239)//Medical Research Council; R01 HD37509/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Paired Box Transcription Factors |
| Comments/Corrections | |
Erratum In:
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Evol Dev. 2006 Mar-Apr;8(2):239 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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