Document Detail


Generality of vertebrate developmental patterns: evidence for a dermomyotome in fish.
MedLine Citation:
PMID:  16409387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The somitic compartment that gives rise to trunk muscle and dermis in amniotes is an epithelial sheet on the external surface of the somite, and is known as the dermomyotome. However, despite its central role in the development of the trunk and limbs, the evolutionary history of the dermomyotome and its role in nonamniotes is poorly understood. We have tested whether a tissue with the morphological and molecular characteristics of a dermomyotome exists in nonamniotes. We show that representatives of the agnathans and of all major clades of gnathostomes each have a layer of cells on the surface of the somite, external to the embryonic myotome. These external cells do not show any signs of terminal myogenic or dermogenic differentiation. Moreover, in the embryos of bony fishes as diverse as sturgeons (Chondrostei) and zebrafish (Teleostei) this layer of cells expresses the pax3 and pax7 genes that mark myogenic precursors. Some of the pax7-expressing cells also express the differentiation-promoting myogenic regulatory factor Myogenin and appear to enter into the myotome. We therefore suggest that the dermomyotome is an ancient and conserved structure that evolved prior to the last common ancestor of all vertebrates. The identification of a dermomyotome in fish makes it possible to apply the powerful cellular and genetic approaches available in zebrafish to the understanding of this key developmental structure.
Authors:
S H Devoto; W Stoiber; C L Hammond; P Steinbacher; J R Haslett; M J F Barresi; S E Patterson; E G Adiarte; S M Hughes
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Evolution & development     Volume:  8     ISSN:  1520-541X     ISO Abbreviation:  Evol. Dev.     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-01-13     Completed Date:  2006-04-04     Revised Date:  2013-04-29    
Medline Journal Info:
Nlm Unique ID:  100883432     Medline TA:  Evol Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  101-10     Citation Subset:  IM    
Affiliation:
Biology Department, Wesleyan University, Middletown, CT 06457, USA. sdevoto@wesleyan.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Gene Expression Regulation, Developmental
Paired Box Transcription Factors / genetics,  metabolism
Phylogeny
Somites / cytology*
Vertebrates / embryology*,  genetics
Grant Support
ID/Acronym/Agency:
G0300213//Medical Research Council; G0300213(65750)//Medical Research Council; G0300213(69239)//Medical Research Council; R01 HD37509/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Paired Box Transcription Factors
Comments/Corrections
Erratum In:
Evol Dev. 2006 Mar-Apr;8(2):239

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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