| Generalised periodic epileptiform discharges: clinical features, neuroradiological evaluation and prognosis in 37 adult patients. | |
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MedLine Citation:
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PMID: 12967574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Generalised periodic epileptiform discharges (GPEDs) are very rare patterns and are classified as periodic short-interval diffuse discharges (PSIDDs), periodic long-interval diffuse discharges (PLIDDs) and suppression-burst patterns according to the interval between the discharges. In this study we analysed the demographics, history of the seizures during the current illness, mental status, diagnosis, metabolic abnormalities, neuroimaging studies and prognosis of 37 adult patients who had GPEDs in their EEGs. Ages ranged from 17 to 82 years (mean 45 years). There were 19 males and 18 females. The most common aetiology of GPEDs was metabolic and/or infectious disease which was established in 22 patients (59.5%). Other aetiologies included subacute sclerosing panencephalitis (SSPE) in 11 patients (29.7%) and Creutzfeld-Jakob disease (CJD) in 4 patients (10.8%). We showed that structural lesions were found in most of the patients with GPEDs, but concurrent metabolic abnormalities and/or infectious diseases were also detected. Consciousness was impaired and clinical conditions were poor in various degrees in all of the patients when GPEDs were seen. Relatively little is known regarding the mechanism of GPEDs. When GPEDs are seen in EEG, the patient should carefully be checked for metabolic abnormalities and/or infectious diseases and intracranial lesions. GPEDs may be helpful in the determination of prognosis, showing the poor prognosis especially in cases when suppression-burst pattern is seen. |
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Authors:
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Muge Yemisci; Gunfer Gurer; Serap Saygi; Abdurrahman Ciger |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seizure : the journal of the British Epilepsy Association Volume: 12 ISSN: 1059-1311 ISO Abbreviation: Seizure Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-09-11 Completed Date: 2003-11-21 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9306979 Medline TA: Seizure Country: England |
Other Details:
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Languages: eng Pagination: 465-72 Citation Subset: IM |
Affiliation:
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Department of Neurology, Hacettepe University Hospitals, Ankara, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Brain Diseases, Metabolic / complications, physiopathology Brain Mapping Creutzfeldt-Jakob Syndrome / complications, diagnosis Demography* Electroencephalography Encephalitis / complications, diagnosis Epilepsy, Generalized / diagnosis*, epidemiology, physiopathology Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods Male Middle Aged Mortality Neuroradiography / methods* Prognosis |
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