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General consideration on sialic Acid chemistry.
MedLine Citation:
PMID:  22057516     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Sialic acids, also known as neuraminic acids, are a family of negatively charged α-keto acids with a nine-carbon backbone. These unique sugars have been found at the termini of many glycan chains of vertebrate cell surface, which play pivotal roles in mediating or modulating a variety of physiological and pathological processes. This brief review covers general approaches for synthesizing sialic acid containing structures. Recently developed synthetic methods along with structural diversities and biological functions of sialic acid are discussed.
Authors:
Hongzhi Cao; Xi Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  808     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2012  
Date Detail:
Created Date:  2011-11-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  31-56     Citation Subset:  IM    
Affiliation:
National Glycoengineering Research Center, Shandong University, Jinan, Shandong, People's Republic of China, hzcao@sdu.edu.cn.
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