Document Detail


General anesthesia alters time perception by phase shifting the circadian clock.
MedLine Citation:
PMID:  22509009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Following general anesthesia, people are often confused about the time of day and experience sleep disruption and fatigue. It has been hypothesized that these symptoms may be caused by general anesthesia affecting the circadian clock. The circadian clock is fundamental to our well-being because it regulates almost all aspects of our daily biochemistry, physiology, and behavior. Here, we investigated the effects of the most common general anesthetic, isoflurane, on time perception and the circadian clock using the honeybee (Apis mellifera) as a model. A 6-h daytime anesthetic systematically altered the time-compensated sun compass orientation of the bees, with a mean anticlockwise shift in vanishing bearing of 87° in the Southern Hemisphere and a clockwise shift in flight direction of 58° in the Northern Hemisphere. Using the same 6-h anesthetic treatment, time-trained bees showed a delay in the start of foraging of 3.3 h, and whole-hive locomotor-activity rhythms were delayed by an average of 4.3 h. We show that these effects are all attributable to a phase delay in the core molecular clockwork. mRNA oscillations of the central clock genes cryptochrome-m and period were delayed by 4.9 and 4.3 h, respectively. However, this effect is dependent on the time of day of administration, as is common for clock effects, and nighttime anesthesia did not shift the clock. Taken together, our results suggest that general anesthesia during the day causes a persistent and marked shift of the clock effectively inducing "jet lag" and causing impaired time perception. Managing this effect in humans is likely to help expedite postoperative recovery.
Authors:
James F Cheeseman; Eva C Winnebeck; Craig D Millar; Lisa S Kirkland; James Sleigh; Mark Goodwin; Matt D M Pawley; Guy Bloch; Konstantin Lehmann; Randolf Menzel; Guy R Warman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-16
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-02     Completed Date:  2012-07-10     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7061-6     Citation Subset:  IM    
Affiliation:
Department of Anaesthesiology, School of Medicine, University of Auckland, Auckland 1142, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Activity Cycles / drug effects,  physiology
Anesthesia, General / adverse effects*
Anesthetics, General / adverse effects
Animals
Base Sequence
Bees / drug effects,  genetics,  physiology*
Circadian Clocks / drug effects,  genetics,  physiology*
Feeding Behavior / drug effects,  physiology
Flight, Animal / drug effects,  physiology
Genes, Insect
Humans
Isoflurane / adverse effects
Models, Animal
Photoperiod
RNA, Messenger / genetics,  metabolism
Time Perception / drug effects,  physiology*
Chemical
Reg. No./Substance:
0/Anesthetics, General; 0/RNA, Messenger; 26675-46-7/Isoflurane
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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