| General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain. | |
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MedLine Citation:
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PMID: 16738805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Brain-derived neurotrophic factor (BDNF) is important in supporting neuronal development. BDNF imbalance due to excessive neuronal inhibition can result in the apoptotic degeneration of developing neurons. Since general anesthetics cause profound depression of neuronal activity and are known to induce widespread degeneration in the developing brain, we studied their potential to activate BDNF-mediated developmental neuroapoptosis. When P7 rats (at the peak of brain development) were exposed to a commonly-used and highly pro-apoptotic anesthesia protocol (midazolam, isoflurane, nitrous oxide) for a period of 2, 4 or 6 h, we found that anesthesia modulates the key steps in BDNF-activated apoptotic cascade in two of the most vulnerable brain regions--cerebral cortex and thalamus in time-dependent fashion by activating both Trk-dependent (in thalamus) and Trk-independent p75NTR dependent (in cerebral cortex) neurotrophic pathways. beta-estradiol, a sex hormone that upregulates the protein levels of the activated Akt, protects against anesthesia-induced neuroapoptosis. |
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Authors:
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Lucy X Lu; Jun-Heum Yon; Lisa B Carter; Vesna Jevtovic-Todorovic |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Apoptosis : an international journal on programmed cell death Volume: 11 ISSN: 1360-8185 ISO Abbreviation: Apoptosis Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-20 Completed Date: 2006-12-14 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9712129 Medline TA: Apoptosis Country: United States |
Other Details:
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Languages: eng Pagination: 1603-15 Citation Subset: IM |
Affiliation:
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Department of Anasthesiology, University of Virginia Health System, P.O. Box 800710, Charlottesville, 22908, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, General
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adverse effects* Anesthetics / adverse effects, pharmacology Animals Apoptosis / drug effects*, physiology Brain / drug effects, growth & development* Brain-Derived Neurotrophic Factor / metabolism, physiology* Cerebral Cortex / drug effects, growth & development Down-Regulation / drug effects Estradiol / pharmacology Models, Biological Nerve Degeneration / chemically induced Neurons / drug effects* Oncogene Protein v-akt / metabolism Oncogene Proteins / metabolism Rats Rats, Sprague-Dawley Respiratory Insufficiency / chemically induced Signal Transduction / drug effects Thalamus / drug effects, growth & development |
| Grant Support | |
ID/Acronym/Agency:
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AG 11355/AG/NIA NIH HHS; HD 44517/HD/NICHD NIH HHS; K08-DA00406/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics; 0/Brain-Derived Neurotrophic Factor; 0/Oncogene Proteins; 0/oncogene protein trk; 50-28-2/Estradiol; EC 2.7.11.1/Oncogene Protein v-akt |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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