Document Detail

General anaesthetics: effects on transmitter release.
MedLine Citation:
PMID:  2858431     Owner:  NLM     Status:  MEDLINE    
In this report, the physiological effects, observations and events leading to transmitter release in both central nervous system and peripheral synapses are discussed. The presynaptic modulation of transmission at the central nervous system and at the neuromuscular junction was investigated using electrophysiological and neurochemical techniques. It was concluded that various general anaesthetics may affect the presynaptic mechanism of transmission, but these effects were controversial. For example, terminal excitability, which is taken as an index for presynaptic activity, could either be reduced or increased by general anaesthetics. Similar conflicting effects have been reported for the action of general anaesthetics on spontaneous and evoked release of ACh, uptake and release of intracellular Ca2+, and choline transport into the presynaptic nerve terminals.
F A Wali
Publication Detail:
Type:  In Vitro; Journal Article; Review    
Journal Detail:
Title:  General pharmacology     Volume:  16     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-04-26     Completed Date:  1985-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  7-11     Citation Subset:  IM    
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MeSH Terms
Action Potentials / drug effects
Anesthesia, General*
Biological Transport / drug effects
Calcium / metabolism
Choline / metabolism
Muscle Contraction / drug effects
Nerve Endings / drug effects
Neural Conduction / drug effects
Neurotransmitter Agents / biosynthesis,  metabolism*
Synaptic Membranes / drug effects
Synaptic Transmission / drug effects*
Reg. No./Substance:
0/Neurotransmitter Agents; 62-49-7/Choline; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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