| Modern pathology methods for neural investigations. | |
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MedLine Citation:
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PMID: 21212254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This session at the 2010 joint symposium of the Society of Toxicologic Pathology (STP) and the International Federation of Societies of Toxicologic Pathologists (IFSTP) explored modern neuropathology methods for assessing the neurotoxicologic potential of xenobiotics. Conventional techniques to optimally prepare and evaluate the central and peripheral neural tissues while minimizing artifact were reviewed, and optimal schemes were set forth for evaluation of the nervous system during both routine (i.e., general toxicity) studies and enhanced (i.e., specialized neurotoxicity) studies. Stereology was introduced as the most appropriate means of examining the possible impact of toxicants on neural cell numbers. A focused discussion on brain sampling took place among a panel of expert neuroscientists (anatomists and pathologists) and the audience regarding the proper balance between sufficient sampling and cost- and time-effectiveness of the analysis. No consensus was reached on section orientation (coronal sections of both sides vs. a parasagittal longitudinal section with several unilateral hemisections from the contralateral side), but most panelists favored sampling at least 8 sections (or approximately double to triple the current complement) in routine toxicity studies. |
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Authors:
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Sarah L Hale; Lydia Andrews-Jones; William H Jordan; Bernard S Jortner; Rogely W Boyce; John T Boyce; Robert C Switzer Iii; Mark T Butt; Robert H Garman; Karl Jensen; Georg Krinke; Peter B Little |
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Publication Detail:
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Type: Journal Article Date: 2011-01-06 |
Journal Detail:
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Title: Toxicologic pathology Volume: 39 ISSN: 1533-1601 ISO Abbreviation: Toxicol Pathol Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-03-07 Completed Date: 2011-06-23 Revised Date: 2011-07-11 |
Medline Journal Info:
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Nlm Unique ID: 7905907 Medline TA: Toxicol Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 52-7 Citation Subset: IM |
Affiliation:
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Covance Laboratories, Inc., Vienna, VA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Congresses as Topic Evaluation Studies as Topic Humans Nervous System / anatomy & histology* Nervous System Diseases / chemically induced*, pathology* Neurotoxicity Syndromes / pathology Societies, Scientific Toxicity Tests / methods* Xenobiotics / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Xenobiotics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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