Document Detail


General one-pot, two-step protocol accessing a range of novel polycyclic heterocycles with high skeletal diversity.
MedLine Citation:
PMID:  22746181     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An Ugi one-pot three-component four-center reaction was coupled with a subsequent acid mediated cyclodehydration step to furnish a multitude of unique scaffolds having in common an embedded or attached benzimidazole and often a ring system formed through lactamization. Using combinations of tethered Ugi inputs typically via tethered acid-ketone inputs and supporting reagents containing masked internal nucleophiles, such scaffolds were produced in good to excellent yields in an operationally friendly manner.
Authors:
Zhigang Xu; Muhammad Ayaz; Alexandra A Cappelli; Christopher Hulme
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-12
Journal Detail:
Title:  ACS combinatorial science     Volume:  14     ISSN:  2156-8944     ISO Abbreviation:  ACS Comb Sci     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-13     Completed Date:  2012-12-12     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  101540531     Medline TA:  ACS Comb Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  460-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Benzimidazoles / chemistry*
Cyclization
Lactams / chemistry*
Molecular Structure
Polymers / chemistry*
Grant Support
ID/Acronym/Agency:
P41 GM086190/GM/NIGMS NIH HHS; P41GM086190/GM/NIGMS NIH HHS; RC2 MH090878/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Benzimidazoles; 0/Lactams; 0/Polymers; E24GX49LD8/benzimidazole
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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