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Gene variants predisposing to SIDS: current knowledge.
MedLine Citation:
PMID:  20623341     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Genetic risk factors play a role in sudden unexpected infant death; either as a cause of death, such as in cases with medium-chain acyl-coenzyme A dehydrogenase deficiency and cardiac arrest due to long QT syndrome, or as predisposing factors for sudden infant death syndrome (SIDS). Most likely genetic predisposition to SIDS represent a polygenic inheritance pattern leading to sudden death when combined with other risk factors, such as a vulnerable developmental stage of the central nervous system and/or the immune system, in addition to environmental risk factors, such as a common cold or prone sleeping position. Genes involved in the regulation of the immune system, cardiac function, the serotonergic network and brain function and development have so far emerged as the most important with respect to SIDS. The purpose of the present paper is to survey current knowledge on SIDS and possible genetic contributions.
Authors:
Siri H Opdal; Torleiv O Rognum
Publication Detail:
Type:  Journal Article     Date:  2010-07-11
Journal Detail:
Title:  Forensic science, medicine, and pathology     Volume:  7     ISSN:  1556-2891     ISO Abbreviation:  Forensic Sci Med Pathol     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101236111     Medline TA:  Forensic Sci Med Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  26-36     Citation Subset:  IM    
Affiliation:
Institute of Forensic Medicine, University of Oslo, Oslo, Norway, s.h.opdal@medisin.uio.no.
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