| Gene therapy progress and prospects: the skin--easily accessible, but still far away. | |
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MedLine Citation:
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PMID: 16957767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Significant progress has been made in corrective gene therapy of inherited skin diseases. This includes advances in vector technology, targeted gene expression, gene replacement, and the availability of appropriate animal models for a variety of candidate diseases. In addition, an increased understanding of the uptake and trafficking mechanisms inside keratinocytes has evolved. Topical application facilitates DNA vaccination through the skin, albeit clinical benefits have not yet materialized. However, the translation into clinical trials has only been partially mastered. The latter and the control of immune responses represent challenges for the research community. |
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Authors:
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U R Hengge |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-09-07 |
Journal Detail:
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Title: Gene therapy Volume: 13 ISSN: 0969-7128 ISO Abbreviation: Gene Ther. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-07 Completed Date: 2007-07-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421525 Medline TA: Gene Ther Country: England |
Other Details:
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Languages: eng Pagination: 1555-63 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Heinrich-Heine-University, Duesseldorf, Germany. ulrich.hengge@uni-duesseldorf.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals DNA / administration & dosage, immunology Forecasting Gene Expression Gene Therapy / methods, trends* Genetic Vectors / administration & dosage, genetics Humans Models, Animal Skin / immunology, metabolism* Skin Absorption Skin Diseases / genetics*, immunology, therapy Vaccines, DNA / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Vaccines, DNA; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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