| Gene therapy for the prevention of vein graft disease. | |
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MedLine Citation:
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PMID: 23274305 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Ischemic cardiovascular disease remains the leading cause of death worldwide. Despite advances in the medical management of atherosclerosis over the past several decades, many patients require arterial revascularization to reduce mortality and alleviate ischemic symptoms. Technological advancements have led to dramatic increases in the use of percutaneous and endovascular approaches, yet surgical revascularization (bypass surgery) with autologous vein grafts remains a mainstay of therapy for both coronary and peripheral artery disease. Although bypass surgery is highly efficacious in the short term, long-term outcomes are limited by relatively high failure rates as a result of intimal hyperplasia, which is a common feature of vein graft disease. The supply of native veins is limited, and many individuals require multiple grafts and repeat procedures. The need to prevent vein graft failure has led to great interest in gene therapy approaches to this problem. Bypass grafting presents an ideal opportunity for gene therapy, as surgically harvested vein grafts can be treated with gene delivery vectors ex vivo, thereby maximizing gene delivery while minimizing the potential for systemic toxicity and targeting the pathogenesis of vein graft disease at its onset. Here we will review the pathogenesis of vein graft disease and discuss vector delivery strategies and potential molecular targets for its prevention. We will summarize the preclinical and clinical literature on gene therapy in vein grafting and discuss additional considerations for future therapies to prevent vein graft disease. |
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Authors:
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Kevin W Southerland; Sarah B Frazier; Dawn E Bowles; Carmelo A Milano; Christopher D Kontos |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-27 |
Journal Detail:
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Title: Translational research : the journal of laboratory and clinical medicine Volume: - ISSN: 1878-1810 ISO Abbreviation: Transl Res Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101280339 Medline TA: Transl Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Surgery, Division of Surgical Sciences and Division of Cardiovascular and Thoracic Surgery; Department of Medicine, Division of Cardiology; Department of Pharmacology and Cancer Biology; and the Medical Scientist Training Program, Duke University School of Medicine, Duke University Medical Center, Durham, North Carolina. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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