Document Detail


Gene therapy for myocardial infarction-associated congestive heart failure: how far have we got?
MedLine Citation:
PMID:  21701699     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
With the advancement of vectors, delivery methods, and newly identified molecular targets, preclinical studies have shown that gene transfer is effective in improving left ventricular contractility and attenuating deleterious left ventricular remodeling in myocardial infarction-associated congestive heart failure (CHF). We are optimistic that these favorable effects will also be seen when tested in patients with CHF associated with myocardial infarction, as well as in patients with CHF from other etiologies. Gene therapy has the potential to be tailored to meet the needs of individual patients. Moreover, when used in conjunction with pharmacological and device management of the patient with CHF, it provides hope for a brighter future for the 23 million patients worldwide with this devastating disease.
Authors:
H Kirk Hammond; Tong Tang
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Dialogues in cardiovascular medicine : DCM     Volume:  14     ISSN:  1272-9949     ISO Abbreviation:  -     Publication Date:  2009  
Date Detail:
Created Date:  2011-6-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197195     Medline TA:  Dialog Cardiovasc Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  27-51     Citation Subset:  -    
Affiliation:
VA San Diego Healthcare System - San Diego - Calif - USA; Department of Medicine - University of California San Diego - La Jolla - Calif - USA.
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
P01 HL066941-05//NHLBI NIH HHS; R01 HL081741-04//NHLBI NIH HHS; R01 HL088426-04//NHLBI NIH HHS

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