Document Detail


Gene therapy for lung cancer.
MedLine Citation:
PMID:  8695549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The techniques of molecular genetics are being applied in many areas of oncology and have been spectacularly successful in elucidating the pathogenesis of cancer. Attempts are now being made to harness this knowledge for therapeutic use. Lung cancers are common solid tumours of complex aetiology and represent a major challenge for gene therapy.
CURRENT INVESTIGATIONS: The approaches presently under investigation include the correction of acquired genetic abnormalities, such as mutation of p53 and activation of the ras oncogene, immunotherapy, enhancement of host resistance to cytotoxic insult, and genetic activation of prodrugs by tissue-specific promoters. A variety of vector systems arc available, including liposomes, replication-defective retroviruses and adenoviruses. Local, regional and systemic routes of administration are being studied, and it seems likely that a combination of these approaches will be needed if such treatments are to become generally available.
Authors:
P J Woll; I R Hart
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annals of oncology : official journal of the European Society for Medical Oncology / ESMO     Volume:  6 Suppl 1     ISSN:  0923-7534     ISO Abbreviation:  Ann. Oncol.     Publication Date:  1995  
Date Detail:
Created Date:  1996-09-05     Completed Date:  1996-09-05     Revised Date:  2013-07-15    
Medline Journal Info:
Nlm Unique ID:  9007735     Medline TA:  Ann Oncol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  73-7     Citation Subset:  IM    
Affiliation:
Richard Dimbleby/ICRF Department of Cancer Research, Rayne Institute, St. Thomas' Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacokinetics
Biotransformation
Gene Expression Regulation, Neoplastic
Genes, p53
Genes, ras
Genetic Therapy*
Genetic Vectors
Humans
Lung Neoplasms / genetics,  immunology,  therapy*
Lymphocytes, Tumor-Infiltrating / immunology
Mutation
Prodrugs / pharmacokinetics
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Prodrugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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