Document Detail


Gene therapy for dyslipidemia: clinical prospects.
MedLine Citation:
PMID:  11122693     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Current approaches to the treatment of lipid disorders are inadequate for a substantial number of patients with severe hyperlipoproteinemia, isolated low high-density lipoprotein (HDL) cholesterol levels, or other molecular disorders of lipoprotein metabolism. Therefore, dyslipidemias remain important targets for the development of novel therapies. Gene therapy is a logical therapeutic approach to monogenic lipoprotein disorders, such as homozygous familial hypercholesterolemia, familial lipoprotein lipase deficiency, familial lecithin-cholesterol acyltransferase deficiency, and abetalipoproteinemia, for which current therapies are inadequate. Gene therapy could also be used to increase expression of certain proteins, such as apolipoprotein A-I as a strategy to raise HDL cholesterol levels or apoE as a strategy for severe combined hyperlipidemia. With further progress in the development of vectors, gene therapy for severe dyslipidemia is likely to become a clinical reality.
Authors:
D J Rader; U J Tietge
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  1     ISSN:  1523-3804     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  1999 Jul 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-69     Citation Subset:  IM    
Affiliation:
Department of Medicine and Pathology and Laboratory Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104-6100, USA.
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MeSH Terms
Descriptor/Qualifier:
Gene Therapy*
Gene Transfer Techniques
Genetic Vectors
Humans
Hyperlipidemias / genetics,  therapy*
Viruses

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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