| Gene therapy: applications and progress towards the clinic. | |
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MedLine Citation:
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PMID: 15546456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gene therapy was originally conceived as an approach to the treatment of genetic disease, to repair or replace a faulty gene. Subsequently, gene therapy clinical trials have been undertaken for a wide range of conditions, particularly cancer and AIDS. Overall, the results from gene therapy have been disappointing. The reasons include the following: (i) low gene transfer efficiencies and (ii) shortcomings in the identification and manipulation of appropriate target cells, including progenitor cell populations required for the maintenance of long-term effects. Today, the immense potential of gene therapy remains, but more basic research is required to improve technical aspects of this form of cellular therapy. |
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Authors:
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R J A Trent; I E Alexander |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Internal medicine journal Volume: 34 ISSN: 1444-0903 ISO Abbreviation: Intern Med J Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-19 Completed Date: 2005-03-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101092952 Medline TA: Intern Med J Country: Australia |
Other Details:
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Languages: eng Pagination: 621-5 Citation Subset: IM |
Affiliation:
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Department of Molecular and Clinical Genetics, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. rtrent@med.usyd.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Australia Clinical Trials as Topic Gene Therapy / methods, trends* Gene Transfer Techniques / trends* Humans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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