| Gene therapy and angiogenesis in patients with coronary artery disease. | |
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MedLine Citation:
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PMID: 20670190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Not all patients with severe coronary artery disease can be treated satisfactorily with current recommended medications and revascularization techniques. Various vascular growth factors have the potential to induce angiogenesis in ischemic tissue. Clinical trials have only evaluated the effect of VEGF and FGF in patients with coronary artery disease. The initial small and unblinded studies with either recombinant growth factor proteins or genes encoding growth factors were encouraging, demonstrating both clinical improvement and evidence of angiogenesis. However, subsequent larger double-blind placebo-controlled trials could not confirm the initial high efficacy of either the growth factor protein or the gene therapy approaches observed in earlier small trials. The clinical studies so far have all been without any gene-related serious adverse events. Future trials will focus on whether an improvement in clinical results can be obtained with a cocktail of growth factors or by a combination of gene and stem cell therapy in patients with severe coronary artery disease, which cannot be treated effectively with current treatment strategies. |
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Authors:
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Jens Kastrup |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert review of cardiovascular therapy Volume: 8 ISSN: 1744-8344 ISO Abbreviation: Expert Rev Cardiovasc Ther Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-30 Completed Date: 2010-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101182328 Medline TA: Expert Rev Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: 1127-38 Citation Subset: IM |
Affiliation:
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Cardiac Catheterization Laboratory 2014, The Hearth Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. jens.kastrup@rh.regionh.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiogenesis Inducing Agents
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administration & dosage* Animals Clinical Trials as Topic Coronary Artery Disease / physiopathology, therapy* Fibroblast Growth Factors / administration & dosage Gene Therapy / methods* Humans Neovascularization, Physiologic Severity of Illness Index Vascular Endothelial Growth Factors / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inducing Agents; 0/Vascular Endothelial Growth Factors; 62031-54-3/Fibroblast Growth Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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