Document Detail

Gene and protein expression in the myometrium in pregnancy and labor.
MedLine Citation:
PMID:  16672349     Owner:  NLM     Status:  MEDLINE    
Microarray technologies widen our comprehension of the major structural and metabolic transformations which affect the myometrium from the very beginning of pregnancy until parturition. The results are coherent with the mass of information which was accumulated previously, primarily on the basis of studies of selected critical factors. They highlight the activation of precise signaling pathways, some of which may have been previously under evaluated. The remodelling and maturation processes that the myometrium undergoes in pregnancy appear clearly as phenomena which last during the full course of gestation. Comparatively, the onset of labor is perhaps the phenomenon which remains the least well described by these methods of analysis. Nevertheless, genomic studies constitute a necessary first step of orientation and help establishing new links between the generic signaling pathways that are activated during the normal or pathological gestation. These studies also represent an indicative step that will have to be paralleled, in the future, with the results of the systematic proteomic analysis of the myometrium.
Michelle Breuiller-Fouche; Guy Germain
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  131     ISSN:  1470-1626     ISO Abbreviation:  Reproduction     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-04     Completed Date:  2006-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  837-50     Citation Subset:  IM    
Institut National de la Santé et de la Recherche Médicale, Unité 767, Paris, F-75014, France.
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MeSH Terms
Cytokines / genetics,  metabolism*
Gene Expression Profiling
Labor, Obstetric / metabolism
Myometrium / metabolism*
Oligonucleotide Array Sequence Analysis
Pregnancy / metabolism*
Pregnancy Trimesters
Proteins / genetics,  metabolism*
Signal Transduction / physiology*
Reg. No./Substance:
0/Cytokines; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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