Document Detail


Gene profile identifies zinc transporters differentially expressed in normal human organs and human pancreatic cancer.
MedLine Citation:
PMID:  23331012     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deregulated expression of zinc transporters was linked to several cancers. However, the detailed expression profile of all human zinc transporters in normal human organs and in human cancer, especially in pancreatic cancer is not available. The objectives of this study are to investigate the complete expression patterns of 14 ZIP and 10 ZnT transporters in a large number of normal human organs and in human pancreatic cancer tissues and cell lines. We examined the expression patterns of ZIP and ZnT transporters in 22 different human organs and tissues, 11 pairs of clinical human pancreatic cancer specimens and surrounding normal/benign tissues, as well as 10 established human pancreatic cancer cell lines plus normal human pancreatic ductal epithelium (HPDE) cells, using real time RT-PCR and immunohistochemistry. The results indicate that human zinc transporters have tissue specific expression patterns, and may play different roles in different organs or tissues. Almost all the ZIPs except for ZIP4, and most ZnTs were down-regulated in human pancreatic cancer tissues compared to the surrounding benign tissues. The expression patterns of individual ZIPs and ZnTs are similar among different pancreatic cancer lines. Those results and our previous studies suggest that ZIP4 is the only zinc transporter that is significantly up-regulated in human pancreatic cancer and might be the major zinc transporter that plays an important role in pancreatic cancer growth. ZIP4 might serve as a novel molecular target for pancreatic cancer diagnosis and therapy.
Authors:
J Yang; Y Zhang; X Cui; W Yao; X Yu; P Cen; S E Hodges; W E Fisher; F C Brunicardi; C Chen; Q Yao; M Li
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current molecular medicine     Volume:  13     ISSN:  1875-5666     ISO Abbreviation:  Curr. Mol. Med.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-27     Completed Date:  2013-08-15     Revised Date:  2013-10-22    
Medline Journal Info:
Nlm Unique ID:  101093076     Medline TA:  Curr Mol Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  401-9     Citation Subset:  IM    
Affiliation:
Vivian L. Smith Department of Neurosurgery, University of Texas Medical School at Houston, 6431 Fannin Street, MSE R266, Houston, TX 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Cation Transport Proteins / genetics,  metabolism*
Cell Line, Tumor
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Pancreatic Ducts / metabolism
Pancreatic Neoplasms / metabolism*
Up-Regulation
Zinc / metabolism*
Grant Support
ID/Acronym/Agency:
R01 CA138701/CA/NCI NIH HHS; R01CA138701/CA/NCI NIH HHS; R21 CA133604/CA/NCI NIH HHS; R21CA133604/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Cation Transport Proteins; 0/SLC39A4 protein, human; 7440-66-6/Zinc
Comments/Corrections

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