Document Detail


Gene polymorphisms and serum alpha-2-Heremans-Schmid levels in Italian haemodialysis patients.
MedLine Citation:
PMID:  17851232     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Vascular calcification (VC) and accelerated atherosclerosis are major causes of cardiovascular (CV) morbidity and mortality in haemodialysis (HD) patients. Inhibitory proteins are associated with reduced VC and may play a key role in preventing CV in chronic kidney disease (CKD) patients. Fetuin-A, also known as alpha(2)-Heremans-Schmid glycoprotein (AHSG), is a circulating plasma protein with inhibitory effects on VC that has been associated with inflammation and CV mortality in HD patients. In the present study, we investigated the associations between serum fetuin-A levels and its gene (AHSG) polymorphisms in an Italian HD population. METHODS: Ninety-six patients on stable chronic HD treatment and 57 healthy controls were genotyped for the common polymorphisms on the AHSG (T256S). In addition, serum fetuin-A levels were tested. RESULTS: In this study, serum fetuin-A levels were lower in HD patients (0.35 +/- 0.11 g/l) compared with healthy controls (0.62 +/- 0.31 g/l, p < 0.05). In both HD patients and the control group, the distribution of the AHSG gene did not show significant association between low serum fetuin-A levels and the Ser/Ser genotype, known to be associated with a higher CV mortality risk in the HD population. Moreover, the distribution of AHSG gene polymorphisms in HD patients and in healthy controls was similar. CONCLUSIONS: In contrast with previous reports, this study suggests that CKD patients on HD treatment have a similar polymorphism distribution of the AHSG gene compared with the normal population and that the reduction in serum fetuin-A levels in Italian HD patients is not associated with an alteration in the distribution of AHSG T256S polymorphisms.
Authors:
Mario Cozzolino; Maria Luisa Biondi; Andrea Galassi; Maurizio Gallieni; Gian Vico Melzi d'Eril; Diego Brancaccio
Publication Detail:
Type:  Journal Article     Date:  2007-09-11
Journal Detail:
Title:  American journal of nephrology     Volume:  27     ISSN:  1421-9670     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-10-26     Completed Date:  2007-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  639-42     Citation Subset:  IM    
Copyright Information:
(c) 2007 S. Karger AG, Basel.
Affiliation:
Renal Division, S. Paolo Hospital, University of Milan, Milan, Italy. mariocozzolino@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Atherosclerosis / genetics,  metabolism
Blood Proteins / analysis,  genetics*
Calcinosis / genetics*,  metabolism
Cardiovascular Diseases / genetics*,  metabolism
Case-Control Studies
Female
Genotype
Humans
Italy
Kidney Failure, Chronic / complications,  therapy
Male
Middle Aged
Polymorphism, Genetic
Renal Dialysis
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/alpha2HS glycoprotein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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