| Gene polymorphism of myospryn (cardiomyopathy-associated 5) is associated with left ventricular wall thickness in patients with hypertension. | |
| | |
MedLine Citation:
|
PMID: 18344630 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We examined a gene polymorphism of a novel Z-disc-related protein, myospryn (cardiomyopathy-associated 5). We focused on one haplotype block associated with a tag single nucleotide polymorphism (SNP) that covered 16 of 27 coding SNPs with linkage disequilibrium (minor allele frequency 0.413). Screening a myospryn polymorphism (K2906N) in a general health check-up of a rural Japanese population revealed an association with cardiac diseases (p=0.0082). In further analysis of the interaction between K2906N and cardiac function in patients, K2906N was associated with the anteroseptal wall thickness of the left ventricle in a recessive model (p=0.0324) and with the ratio of the peak velocity of the early diastolic filling wave to the peak velocity of atrial filling (A/E) (p=0.0278). In an association study based on left ventricular wall thickness, we found a significant difference in the K2906N genotype between controls and patients with cardiac hypertrophy. These results suggest that the K2906N polymorphism could be clinically associated with left ventricular hypertrophy and diastolic dysfunction independent of known parameters. Although the precise mechanism underlying this association remains to be elucidated, treatment with angiotensin II induced an increase in heart myospryn mRNA level in vitro and in vivo. Our results suggest that the polymorphism of myospryn is associated with left ventricular hypertrophy, and an association between a Z-disc protein and cardiac adaptation in response to pressure overload. |
| | |
Authors:
|
Hironori Nakagami; Yasushi Kikuchi; Tomohiro Katsuya; Ryuichi Morishita; Hiroshi Akasaka; Shigeyuki Saitoh; Hiromi Rakugi; Yasufumi Kaneda; Kazuaki Shimamoto; Toshio Ogihara |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 30 ISSN: 0916-9636 ISO Abbreviation: Hypertens. Res. Publication Date: 2007 Dec |
Date Detail:
|
Created Date: 2008-03-17 Completed Date: 2008-04-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: Japan |
Other Details:
|
Languages: eng Pagination: 1239-46 Citation Subset: IM |
Affiliation:
|
Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita, Japan. nakagami@gts.med.osaka-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Angiotensin II / pharmacology Animals Case-Control Studies Cells, Cultured Disease Models, Animal Female Heart Ventricles / metabolism, pathology, ultrasonography Humans Hypertension / complications*, genetics* Hypertrophy, Left Ventricular / etiology*, genetics*, pathology Linkage Disequilibrium / genetics Male Mice Mice, Inbred C57BL Middle Aged Muscle Proteins / genetics*, metabolism Myocytes, Cardiac / drug effects, metabolism, pathology Polymorphism, Single Nucleotide / genetics* Rats Rats, Sprague-Dawley Vasoconstrictor Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/CMYA5 protein, human; 0/Muscle Proteins; 0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibition of vascular angiotensin-converting enzyme by telmisartan via the peroxisome proliferator-...
Next Document: Angiotensin-converting enzyme inhibitor suppresses activation of calcineurin in renovascular hyperte...