| Gene polymorphism of epidermal growth factor receptor and airway hyperresponsiveness in young allergic subjects without respiratory symptoms. | |
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MedLine Citation:
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PMID: 20357714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Airway hyperresponsiveness (AHR) in young asymptomatic adults with atopy can be one of indicators of future symptomatic asthma. We aimed to investigate genetic association of epidermal growth factor receptor (EGFR) with the asymptomatic AHR. MATERIAL/METHODS: We recruited one-hundred and eighty-nine allergic volunteers (mean age 19.5+/-1.4 y.o.) without history of respiratory symptoms, measured bronchial responsiveness to methacholine (0.3 to 10.0 mg/ml) and classified them into subjects with AHR and those without AHR according to a cutoff level of PC20 (8.0 mg/ml). Then, we genotyped 12 SNPs on EGFR gene, and estimate total imbalance of haplotypes frequencies within haplotype block between two groups. RESULTS: Seventy-two (38.1%) in 189 subjects exhibited 20% decrease in FEV1 from the baseline values by inhalation of methacholine 8.0mg/ml or less. Significant results were observed in the following haplotype block: rs 4947972 - rs 12718945 - rs 2072454 (block-1), rs 4947972 - rs 12718945 - rs 2227983 (block-2), or rs 4947972 - rs 12718945 - rs 2293347 (block-3). In each haplotype block, higher frequency of a haplotype, C-T-C (block-1), C-T-A (block-2) and C-T-A (block-3), was observed in subjects with AHR than in those without AHR (odds ratio and the corresponding P value; 3.289 and 0.00087 (block-1), 3.436 and 0.00055 (block-2), and 4.036 and 0.00181 (block-3), respectively). No significant differences were observed in serological parameters and pulmonary function between two subject groups. CONCLUSIONS: Our results indicate that the EGFR gene polymorphism might be associated with presence of asymptomatic AHR in young allergic adults. |
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Authors:
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Takahiro Yoshikawa; Hiroshi Kanazawa; Junji Tanaka; Shigeo Fujimoto; Takushi Yamamoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 16 ISSN: 1643-3750 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-01 Completed Date: 2010-08-05 Revised Date: 2011-06-14 |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: CR163-171 Citation Subset: IM |
Affiliation:
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Department of Sports Medicine, Osaka City University Graduate School of Medicine, Osaka, 545-8585, Japan. tkhr6719@med.osaka-cu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Alleles Bronchial Hyperreactivity / genetics*, pathology* Female Gene Frequency Genotype Haplotypes Humans Hypersensitivity / genetics*, pathology* Introns Male Methacholine Chloride / pharmacology Models, Genetic Odds Ratio Polymorphism, Genetic* Polymorphism, Single Nucleotide Receptor, Epidermal Growth Factor / genetics* |
| Chemical | |
Reg. No./Substance:
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62-51-1/Methacholine Chloride; EC 2.7.10.1/Receptor, Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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