Document Detail


Gene polymorphism of angiotensin-converting enzyme and angiotensin II type 1 receptor in patients with congestive heart failure.
MedLine Citation:
PMID:  18767410     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The angiotensin converting enzyme (ACE) I/D polymorphism influences the plasmatic ACE levels, the highest being registered in the DD form. Similarly, the DD genotype is frequently associated with a CC homozygote genotype of the AT1 receptors. The polymorphism was studied mainly in hypertensive patients. OBJECTIVES: To investigate the genetic polymorphism of renin angiotensin aldosterone system (RAAS) in patients with heart failure as a possible factor in determining the degree of the RAAS activation. METHODS: The study included 36 NYHA III and IV class heart failure patients, 20 males and 16 females, aged 71.03 +/- 9.52 years. The distribution of ACE gene insertion, deletion (I/D) and AT1 receptors Al166C gene polymorphism were determined. Analyses of ACE and AT1 receptors genotypes were performed by polymerase chain reaction (PCR). RESULTS: The distribution of genetic ACE polymorphism was: D/D-47.22% (17 p); I/D-22.22% (8 p); I/I-30.55% (11 p). The identified AT1 receptors genotypes were as follows: AA-50% (18 p); AC-41.66% (15 p), CC-8.33% (3p). The two types of genetic polymorphism were associated in both the 20 hypertensive patients: DD+AA-35% (7 p); DD+AC -25% (5 p); DD+CC-10% (2 p) and the 16 patients without hypertension: DD+AA-6.25% (lp); DD + AC-18.75% (3p). LEVF was < 40% in 10 patients, 40% of them presenting pathogenetic polymorphism (DD+AC or DD+CC. CONCLUSION: Heart failure patients frequently present combinations of genetic polymorphism of RAAS probably involved in the development of neurohormonal pathogenic mechanism of the disease. This combination may be independent by the association with hypertension, and also in relationship with low ejection fraction.
Authors:
Dana Pop; D Zdrenghea; Lucia Maria Procociuc; Adela Popal
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Romanian journal of internal medicine = Revue roumaine de médecine interne     Volume:  45     ISSN:  1220-4749     ISO Abbreviation:  Rom J Intern Med     Publication Date:  2007  
Date Detail:
Created Date:  2008-09-04     Completed Date:  2008-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304507     Medline TA:  Rom J Intern Med     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  349-54     Citation Subset:  IM    
Affiliation:
Department of Cardiology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. pop7dana@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Case-Control Studies
Female
Genetic Predisposition to Disease / genetics*
Genotype
Heart Failure / genetics*
Humans
Hypertension / genetics
Male
Middle Aged
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic / genetics*
Receptor, Angiotensin, Type 1 / genetics*
Chemical
Reg. No./Substance:
0/Receptor, Angiotensin, Type 1; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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