| Gene-nutrient interactions and gender may modulate the association between ApoA1 and ApoB gene polymorphisms and metabolic syndrome risk. | |
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MedLine Citation:
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PMID: 21122859 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: Dyslipidemia is a key feature of the metabolic syndrome (MetS), which is determined by both genetic and dietary factors. METHODS: We determined the relationships between ApoA1 and ApoB polymorphisms and MetS risk, and whether dietary fat modulates this in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n=1754). RESULTS: ApoB rs512535 and ApoA1 rs670 major G allele homozygotes had increased MetS risk (OR 1.65 [CI 1.24, 2.20], P=0.0006; OR 1.42 [CI 1.08, 1.87], P=0.013), which may be, partly, explained by their increased abdominal obesity and impaired insulin sensitivity (P<0.05) but not dyslipidemia. Interestingly these associations derived primarily from the male GG homozygotes (ApoB rs512535 OR 1.92 [CI 1.31, 2.81], P=0.0008; ApoA1 rs670 OR 1.50 [CI 1.05, 2.12], P=0.024). MetS risk was exacerbated among the habitual high-fat consumers (>35% energy) (ApoB rs512535 OR 2.00 [CI 1.14, 3.51], P=0.015; OR 1.58 [CI 1.11, 2.25], P=0.012 for ApoA1 rs670). In addition a high monounsaturated fat (MUFA) intake (>14% energy) increased MetS risk (OR 1.89 [CI 1.08, 3.30], P=0.026 and OR 1.57 [CI 1.10, 2.40], P=0.014 for ApoB rs512535 and ApoA1 rs670, respectively). MetS risk was abolished among the habitual low-fat consumers (<35% energy). Saturated and polyunsaturated fat intake did not modulate MetS risk. CONCLUSION: ApoB rs512535 and ApoA1 rs670 may influence MetS risk. Apparent modulation of these associations by gender and dietary fat composition suggests novel gene-gender-diet interactions. |
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Authors:
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Catherine M Phillips; Louisa Goumidi; Sandrine Bertrais; Martyn R Field; Ross McManus; Serge Hercberg; Denis Lairon; Richard Planells; Helen M Roche |
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Publication Detail:
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Type: Journal Article Date: 2010-11-03 |
Journal Detail:
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Title: Atherosclerosis Volume: 214 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 408-14 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Nutrigenomics Research Group, UCD Conway Institute, UCD School of Public Health and Population Science, University College Dublin, Belfield, Dublin 4, Ireland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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