Document Detail

Gene-gene interaction analysis of personality traits in a Japanese population using an electrochemical DNA array chip analysis.
MedLine Citation:
PMID:  17208375     Owner:  NLM     Status:  MEDLINE    
It has been suggested that genes involved in the central dopaminergic pathway may contribute to personality traits. However, the results of association studies for these genes have not been consistent. The present study investigated the relationship between the specific polymorphisms of MAO-A, COMT, DRD2, DRD3 and personality traits in Japanese women using a novel genotyping method involving electrochemical DNA array (ECA) chip analysis. Single marker association analysis for each mutation revealed no significant association between scores for Neuroticism Extraversion Openness-Five Factor Inventory (NEO-FFI) items. Gene-gene interaction analysis showed that a MAO-A 30-bp repeatxCOMT (Val158Met)xDRD3 (Ser9Gly) had a marginally significant association with Agreeableness (P=0.0547). The present results suggest that a combination of polymorphisms of MAO-A, COMT, and DRD3 might affect personality traits in Japanese women.
Tomohiro Urata; Nagahide Takahashi; Yuko Hakamata; Yoshimi Iijima; Natsumi Kuwahara; Norio Ozaki; Yutaka Ono; Masahiko Amano; Toshiya Inada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-22
Journal Detail:
Title:  Neuroscience letters     Volume:  414     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-02     Completed Date:  2007-06-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  209-12     Citation Subset:  IM    
TUM Gene Inc., Chiba, Japan.
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MeSH Terms
Asian Continental Ancestry Group / genetics
Brain / metabolism*
Brain Chemistry / genetics*
Catechol O-Methyltransferase / genetics
DNA Mutational Analysis
Dopamine / metabolism*
Gene Expression Profiling
Gene Expression Regulation / genetics*
Genetic Markers / genetics
Genetic Testing
Monoamine Oxidase / genetics
Nerve Tissue Proteins / genetics*
Oligonucleotide Array Sequence Analysis
Personality / genetics*
Polymorphism, Genetic / genetics
Receptors, Dopamine D2 / genetics
Receptors, Dopamine D3 / genetics
Reg. No./Substance:
0/Genetic Markers; 0/Nerve Tissue Proteins; 0/Receptors, Dopamine D2; 0/Receptors, Dopamine D3; EC Oxidase; EC O-Methyltransferase

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