| Gene expression of tyrosine hydroxylase in the developing fetal brain. | |
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MedLine Citation:
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PMID: 1975836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tyrosine hydroxylase, aromatic L-amino-acid decarboxylase, and dopamine beta-hydroxylase activities were studied in the developing fetal rat brain. A delay of 2-3 days between the detection of the tyrosine hydroxylase and the aromatic L-amino-acid decarboxylase and dopamine beta-hydroxylase activities was observed. For this reason, the expression of tyrosine hydroxylase mRNA was studied. Tyrosine hydroxylase mRNA was visualized in the whole brain from 13 days of gestation, but the largest increase of the expression was observed in the hypothalamus. These results are discussed in terms of the relative gene expressions of the three enzymes involved in the biosynthesis of catecholamines and phenolamines in nervous tissues. |
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Authors:
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J F Coulon; N F Biguet; A Cavoy; J Delacour; J Mallet; J C David |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurochemistry Volume: 55 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1990 Oct |
Date Detail:
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Created Date: 1990-10-17 Completed Date: 1990-10-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1412-7 Citation Subset: IM |
Affiliation:
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Laboratoire de Biochimie du Développement, Université de Rennes I, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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genetics Animals Aromatic-L-Amino-Acid Decarboxylases / metabolism Blotting, Northern Brain / embryology*, enzymology Dopamine beta-Hydroxylase / metabolism Fetus Gene Expression Regulation, Enzymologic* Gestational Age Organ Specificity RNA, Messenger / analysis, genetics Rats Rats, Inbred Strains Tyrosine 3-Monooxygenase / genetics*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/RNA, Messenger; EC 1.14.16.2/Tyrosine 3-Monooxygenase; EC 1.14.17.1/Dopamine beta-Hydroxylase; EC 4.1.1.28/Aromatic-L-Amino-Acid Decarboxylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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