Document Detail

Gene expression of tyrosine hydroxylase in the developing fetal brain.
MedLine Citation:
PMID:  1975836     Owner:  NLM     Status:  MEDLINE    
Tyrosine hydroxylase, aromatic L-amino-acid decarboxylase, and dopamine beta-hydroxylase activities were studied in the developing fetal rat brain. A delay of 2-3 days between the detection of the tyrosine hydroxylase and the aromatic L-amino-acid decarboxylase and dopamine beta-hydroxylase activities was observed. For this reason, the expression of tyrosine hydroxylase mRNA was studied. Tyrosine hydroxylase mRNA was visualized in the whole brain from 13 days of gestation, but the largest increase of the expression was observed in the hypothalamus. These results are discussed in terms of the relative gene expressions of the three enzymes involved in the biosynthesis of catecholamines and phenolamines in nervous tissues.
J F Coulon; N F Biguet; A Cavoy; J Delacour; J Mallet; J C David
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  55     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1990-10-17     Completed Date:  1990-10-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1412-7     Citation Subset:  IM    
Laboratoire de Biochimie du Développement, Université de Rennes I, France.
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MeSH Terms
Actins / genetics
Aromatic-L-Amino-Acid Decarboxylases / metabolism
Blotting, Northern
Brain / embryology*,  enzymology
Dopamine beta-Hydroxylase / metabolism
Gene Expression Regulation, Enzymologic*
Gestational Age
Organ Specificity
RNA, Messenger / analysis,  genetics
Rats, Inbred Strains
Tyrosine 3-Monooxygenase / genetics*,  metabolism
Reg. No./Substance:
0/Actins; 0/RNA, Messenger; EC 3-Monooxygenase; EC beta-Hydroxylase; EC Decarboxylases

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