| Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos. | |
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MedLine Citation:
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PMID: 11114168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation. |
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Authors:
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L Zakin; B Reversade; B Virlon; C Rusniok; P Glaser; J M Elalouf; P Brulet |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 97 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-01-16 Completed Date: 2001-02-15 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 14388-93 Citation Subset: IM |
Affiliation:
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Unité d'Embyologie Moléculaire, Unité de Recherche Associée 1947, Centre National de la Recherche Scientifique, and Laboratoire de Génomique des Microorganismes Pathogènes, Institut Pasteur, 25 Rue du Docteur Roux, 75724, Paris Cedex 15, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cystatin B Cystatins / genetics Ectoderm Embryonic and Fetal Development Endoderm Expressed Sequence Tags Female Fibroblast Growth Factors / genetics Gastrula / physiology* Gene Expression Profiling* Genotype Head / embryology* Homeodomain Proteins / genetics, physiology* Humans In Situ Hybridization Intercellular Signaling Peptides and Proteins Male Mice Mice, Knockout Nerve Tissue Proteins / genetics, physiology* Nodal Protein Otx Transcription Factors Polycomb Repressive Complex 2 Proteins / genetics Proto-Oncogene Proteins / genetics Repressor Proteins / genetics, physiology Trans-Activators / genetics, physiology* Transcription Factors Transforming Growth Factor beta / genetics Wnt Proteins Wnt4 Protein |
| Chemical | |
Reg. No./Substance:
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0/CSTB protein, human; 0/Cer1 protein, mouse; 0/Cstb protein, mouse; 0/Cystatins; 0/DKK1 protein, human; 0/Dkk1 protein, mouse; 0/EED protein, human; 0/Eed protein, mouse; 0/HHEX protein, human; 0/Hhex protein, mouse; 0/Homeodomain Proteins; 0/Intercellular Signaling Peptides and Proteins; 0/NODAL protein, human; 0/Nerve Tissue Proteins; 0/Nodal Protein; 0/Nodal protein, mouse; 0/OTX2 protein, human; 0/Otx Transcription Factors; 0/Otx2 protein, mouse; 0/Proteins; 0/Proto-Oncogene Proteins; 0/Repressor Proteins; 0/Trans-Activators; 0/Transcription Factors; 0/Transforming Growth Factor beta; 0/WNT4 protein, human; 0/Wnt Proteins; 0/Wnt4 Protein; 0/Wnt4 protein, mouse; 0/fibroblast growth factor 15, mouse; 62031-54-3/Fibroblast Growth Factors; 88844-95-5/Cystatin B; EC 2.1.1.43/Polycomb Repressive Complex 2 |
| Comments/Corrections | |
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