Document Detail


Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos.
MedLine Citation:
PMID:  11114168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation.
Authors:
L Zakin; B Reversade; B Virlon; C Rusniok; P Glaser; J M Elalouf; P Brulet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  97     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-16     Completed Date:  2001-02-15     Revised Date:  2013-04-16    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  14388-93     Citation Subset:  IM    
Affiliation:
Unité d'Embyologie Moléculaire, Unité de Recherche Associée 1947, Centre National de la Recherche Scientifique, and Laboratoire de Génomique des Microorganismes Pathogènes, Institut Pasteur, 25 Rue du Docteur Roux, 75724, Paris Cedex 15, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cystatin B
Cystatins / genetics
Ectoderm
Embryonic and Fetal Development
Endoderm
Expressed Sequence Tags
Female
Fibroblast Growth Factors / genetics
Gastrula / physiology*
Gene Expression Profiling*
Genotype
Head / embryology*
Homeodomain Proteins / genetics,  physiology*
Humans
In Situ Hybridization
Intercellular Signaling Peptides and Proteins
Male
Mice
Mice, Knockout
Nerve Tissue Proteins / genetics,  physiology*
Nodal Protein
Otx Transcription Factors
Polycomb Repressive Complex 2
Proteins / genetics
Proto-Oncogene Proteins / genetics
Repressor Proteins / genetics,  physiology
Trans-Activators / genetics,  physiology*
Transcription Factors
Transforming Growth Factor beta / genetics
Wnt Proteins
Wnt4 Protein
Chemical
Reg. No./Substance:
0/CSTB protein, human; 0/Cer1 protein, mouse; 0/Cstb protein, mouse; 0/Cystatins; 0/DKK1 protein, human; 0/Dkk1 protein, mouse; 0/EED protein, human; 0/Eed protein, mouse; 0/HHEX protein, human; 0/Hhex protein, mouse; 0/Homeodomain Proteins; 0/Intercellular Signaling Peptides and Proteins; 0/NODAL protein, human; 0/Nerve Tissue Proteins; 0/Nodal Protein; 0/Nodal protein, mouse; 0/OTX2 protein, human; 0/Otx Transcription Factors; 0/Otx2 protein, mouse; 0/Proteins; 0/Proto-Oncogene Proteins; 0/Repressor Proteins; 0/Trans-Activators; 0/Transcription Factors; 0/Transforming Growth Factor beta; 0/WNT4 protein, human; 0/Wnt Proteins; 0/Wnt4 Protein; 0/Wnt4 protein, mouse; 0/fibroblast growth factor 15, mouse; 62031-54-3/Fibroblast Growth Factors; 88844-95-5/Cystatin B; EC 2.1.1.43/Polycomb Repressive Complex 2
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