Document Detail

Gene expression profile and aortic vessel distensibility in voluntarily exercised spontaneously hypertensive rats: potential role of heat shock proteins.
MedLine Citation:
PMID:  15914578     Owner:  NLM     Status:  MEDLINE    
Physical exercise is considered to be beneficial for cardiovascular health. Nevertheless, the underlying specific molecular mechanisms still remain unexplored. In this study, we aimed to investigate the effects of voluntary exercise on vascular mechanical properties and gene regulation patterns in spontaneously hypertensive rats. By using ultrasound biomicroscopy in an ex vivo perfusion chamber, we studied the distensibility of the thoracic aorta. Furthermore, exercise-induced gene regulation was studied in aortae, using microarray analysis and validated with real-time PCR. We found that distensibility was significantly improved in aortas from exercising compared with control rats (P < 0.0001). Exercising rats demonstrated a striking pattern of coordinated downregulation of genes belonging to the heat shock protein family. In conclusion, voluntary exercise leads to improved vessel wall distensibility and reduced gene expression of heat shock protein 60 and 70, which may indicate decreased oxidative stress in the aortic vascular wall.
Ulrika Hägg; Maria E Johansson; Julia Grönros; Andrew S Naylor; Ingibjörg H Jonsdottir; Göran Bergström; Per-Arne Svensson; Li-ming Gan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-05-24
Journal Detail:
Title:  Physiological genomics     Volume:  22     ISSN:  1531-2267     ISO Abbreviation:  Physiol. Genomics     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-15     Completed Date:  2006-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9815683     Medline TA:  Physiol Genomics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319-26     Citation Subset:  IM    
Department of Physiology, Institute of Physiology and Pharmacology, Göteborg University, Sweden.
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MeSH Terms
Aorta, Thoracic / metabolism*
Chaperonin 60 / metabolism
DNA Primers / chemistry
DNA, Complementary / metabolism
Gene Expression Profiling*
Gene Expression Regulation*
HSP70 Heat-Shock Proteins / metabolism
Heat-Shock Proteins / metabolism*
Models, Statistical
Oligonucleotide Array Sequence Analysis
Oxidative Stress
Physical Conditioning, Animal*
Polymerase Chain Reaction
RNA / metabolism
Rats, Inbred SHR
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
0/Chaperonin 60; 0/DNA Primers; 0/DNA, Complementary; 0/HSP70 Heat-Shock Proteins; 0/Heat-Shock Proteins; 63231-63-0/RNA

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