| Gene expression profile and aortic vessel distensibility in voluntarily exercised spontaneously hypertensive rats: potential role of heat shock proteins. | |
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MedLine Citation:
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PMID: 15914578 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Physical exercise is considered to be beneficial for cardiovascular health. Nevertheless, the underlying specific molecular mechanisms still remain unexplored. In this study, we aimed to investigate the effects of voluntary exercise on vascular mechanical properties and gene regulation patterns in spontaneously hypertensive rats. By using ultrasound biomicroscopy in an ex vivo perfusion chamber, we studied the distensibility of the thoracic aorta. Furthermore, exercise-induced gene regulation was studied in aortae, using microarray analysis and validated with real-time PCR. We found that distensibility was significantly improved in aortas from exercising compared with control rats (P < 0.0001). Exercising rats demonstrated a striking pattern of coordinated downregulation of genes belonging to the heat shock protein family. In conclusion, voluntary exercise leads to improved vessel wall distensibility and reduced gene expression of heat shock protein 60 and 70, which may indicate decreased oxidative stress in the aortic vascular wall. |
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Authors:
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Ulrika Hägg; Maria E Johansson; Julia Grönros; Andrew S Naylor; Ingibjörg H Jonsdottir; Göran Bergström; Per-Arne Svensson; Li-ming Gan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-05-24 |
Journal Detail:
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Title: Physiological genomics Volume: 22 ISSN: 1531-2267 ISO Abbreviation: Physiol. Genomics Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-15 Completed Date: 2006-06-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9815683 Medline TA: Physiol Genomics Country: United States |
Other Details:
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Languages: eng Pagination: 319-26 Citation Subset: IM |
Affiliation:
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Department of Physiology, Institute of Physiology and Pharmacology, Göteborg University, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Aorta, Thoracic / metabolism* Chaperonin 60 / metabolism DNA Primers / chemistry DNA, Complementary / metabolism Down-Regulation Female Gene Expression Profiling* Gene Expression Regulation* HSP70 Heat-Shock Proteins / metabolism Heat-Shock Proteins / metabolism* Immunohistochemistry Models, Statistical Oligonucleotide Array Sequence Analysis Oxidative Stress Perfusion Physical Conditioning, Animal* Polymerase Chain Reaction RNA / metabolism Rats Rats, Inbred SHR Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/Chaperonin 60; 0/DNA Primers; 0/DNA, Complementary; 0/HSP70 Heat-Shock Proteins; 0/Heat-Shock Proteins; 63231-63-0/RNA |
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