| Gene-expression phenotypes for vascular invasiveness of hepatocellular carcinomas. | |
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MedLine Citation:
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PMID: 19945130 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Gross vascular invasion is a well-established prognostic indicator in hepatocellular carcinoma (HCC), but the biological significance of microscopic invasion remains unclear. METHODS: Curatively resected primary HCCs were classified retrospectively into 3 groups: HCCs without vascular invasion (V0), HCCs with microvascular invasion (V1), and HCCs with macrovascular invasion (V2). Microarray profiling of patients with V0, V1, and V2 using Jonckheere-Terpstra (JT) tests and Wilcoxon rank sum tests was performed. RESULTS: Distinct patterns of gene expression were demonstrated between V0 and V2 groups; less (L) and highly (H) invasive phenotypes, respectively. It is noteworthy that 2 dendrograms by the hierarchical clustering provided exactly the same assignment results for V1 cases that were thus separated into L and H gene-expression phenotypes. Marked differences were found in overall (P < .001) and tumor-free survival (P < .001) between L and H gene-expression phenotypes. Multivariate analyses indicated that the phenotypes of the patterns of gene expression, rather than the clinicopathologic markers of vascular invasion, were independent predictors of tumor recurrence (P = .031). Using the gene-expression patterns identified by both JT and Wilcoxon rank sum test analyses, other V1 cases validated these differences in tumor-free survivals between gene-expression phenotypes within the group (P = .039). CONCLUSION: Gene profiling suggested that microvascular invasiveness consisted of a classable mixture of 2 distinct phenotypes. Thus, gene-array analyses may have clinical benefit, because they may in fact be more predictive than other clinical factors. |
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Authors:
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Shinji Tanaka; Kaoru Mogushi; Mahmut Yasen; Norio Noguchi; Atsushi Kudo; Noriaki Nakamura; Koji Ito; Yoshio Miki; Johji Inazawa; Hiroshi Tanaka; Shigeki Arii |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-27 |
Journal Detail:
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Title: Surgery Volume: 147 ISSN: 1532-7361 ISO Abbreviation: Surgery Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-23 Completed Date: 2010-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: United States |
Other Details:
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Languages: eng Pagination: 405-14 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Hepato-Biliary-Pancreatic Surgery, Tokyo Medical and Dental University, Tokyo, Japan. shinji.msrg@tmd.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Hepatocellular / genetics*, pathology*, surgery Cohort Studies Female Gene Expression Profiling Hepatectomy Hepatic Veins / pathology Humans Liver Neoplasms / genetics*, pathology*, surgery Male Multigene Family Neoplasm Invasiveness Phenotype* Portal Vein / pathology Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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