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Gene expression patterns of vascular endothelial growth factor (VEGF-A) in human placenta from pregnancies with intrauterine growth restriction.
MedLine Citation:
PMID:  23350655     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: In this study, we describe changes in gene expression pattern of VEGF-A in human placenta obtained from pregnancies with intrauterine growth restriction using placenta from normal pregnancies as control. Methods: We compared gene expression of VEGF-A in placental samples from IUGR pregnancies vs. placenta obtained from normal pregnancies. Among potential confounders, important clinical informations were also analyzed. Results: In the IUGR group, the VEGF-A gene was overexpressed compared to the normal pregnancy group (Ln 2(α)(β-actin): 1.32; Ln 2(α)(GADPH): 1.56). There was no correlation between the degree of growth restriction and VEGF-A gene expression (Ln 2(α)(0-5 percentile): 0.58; Ln 2(α)(5-10 percentile): 0.64). Within the IUGR group, there was a trend toward a positive correlation between placental VEGF-A gene activity and gestational age at delivery (Ln2(α)(<33 weeks): 1.09; Ln2(α)(33-37 weeks): 1.27; Ln2(α)(>37 weeks): 1.35). Conclusions: Our findings suggest that the increase in placental expression of the VEGF-A gene and the resultant stimulation of angiogenesis are a response to hypoxic environment developing in the placental tissue in IUGR. Thus, it appears to be a secondary event rather than a primary factor in the development of IUGR There is a trend toward a positive correlation between gestational age and placental VEGF-A gene activity.
Authors:
Imre Szentpéteri; Attila Rab; László Kornya; Péter Kovács; József Gábor Joó
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-28
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Praxis für Gynäkologie und Geburtshilfe und allgemeine Medizin, Wehingen , Baden-Württemberg , Germany.
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