Document Detail


Gene-expression patterns predict phenotypes of immune-mediated thrombosis.
MedLine Citation:
PMID:  16263789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antiphospholipid antibody syndrome (APS) is a complex autoimmune thrombotic disorder with defined clinical phenotypes. Although not all patients with elevated antiphospholipid antibody (aPLA) levels develop complications, the severity of these potential events mandates aggressive and extended lifelong anti-thrombotic therapy. One hundred twenty-nine patients (57 patients with APS and venous thromboembolism [VTE], 32 patients with VTE without aPLA, 32 patients with aPLA only, and 8 healthy patients) were enrolled. RNA from peripheral-blood collection was used for DNA microarray analysis. Patterns of gene expression that characterize APS as well as thrombosis in the presence of aPLA were identified by hierarchical clustering and binary regression methods. Gene-expression profiles identify and predict individuals with APS from patients with VTE without aPLA. Importantly, similar methods identified expression profiles that accurately predicted those patients with aPLA at high risk for thrombotic events. All profiles were validated in independent cohorts of patients. The ability to predict APS, but more importantly, those patients at risk for venous thrombosis, represents a paradigm for a genomic approach that can be applied to other populations of patients with venous thrombosis, providing for more effective clinical management of disease, while also reflecting the possible underlying biologic processes.
Authors:
Anil Potti; Andrea Bild; Holly K Dressman; Deborah A Lewis; Joseph R Nevins; Thomas L Ortel
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Retracted Publication     Date:  2005-11-01
Journal Detail:
Title:  Blood     Volume:  107     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-04-04     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1391-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Duke University Medical Center, Box 3841 Red Zone, Durham, NC 27710, USA. anil.potti@duke.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antibodies, Antiphospholipid / blood*
Antiphospholipid Syndrome / genetics*,  immunology*
Female
Gene Expression Regulation*
Humans
Male
Middle Aged
Oligonucleotide Array Sequence Analysis
Reference Values
Thromboembolism / epidemiology,  genetics*,  immunology
Grant Support
ID/Acronym/Agency:
R01HL072208/HL/NHLBI NIH HHS; U18 DD00014/DD/NCBDD CDC HHS; U54-HL077878/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Antiphospholipid
Comments/Corrections
Retraction In:
Blood. 2011 Oct 20;118(16):4497   [PMID:  21856862 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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