Document Detail


Gene expression of neuropeptide Y in the nucleus of the solitary tract is activated in rats under restricted daily feeding but not under 48-h food deprivation.
MedLine Citation:
PMID:  12786976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The two neuropeptide Y (NPY) systems innervating the hypothalamic paraventrivular nucleus were examined regarding their roles in the prefeeding corticosterone peak developed under restricted daily feeding (RF). Protein and mRNA levels of NPY were measured in the arcuate nucleus (ARC) and the nucleus of the solitary tract (NST) in rats under 48-h food deprivation (48-hFD), RF, and 72-h food deprivation imposed after RF (post-RF 72-hFD) with 7 days of ad libitum feeding in between. NPY protein and mRNA levels in the ARC significantly increased with 48-hFD and decreased with re-feeding, whereas those in the NST were not changed by 48-hFD. When rats had RF imposed with free access to food from 10.00 to 12.00 h (lights on from 06.00 to 18.00 h) for 3 weeks, NPY concentrations in the ARC increased at 10.00 h, just prior to the daily meal, but those in the NST did not change significantly throughout the period examined. On the other hand, NPY mRNA levels in both the ARC and NST increased before the meal supply and remained high for 4 h after feeding. Under post-RF 72-hFD, the prefeeding peak of NPY mRNA was detected in the NST, but NPY mRNA levels in the ARC were continuously high throughout the 24-h period. These findings indicate that the NPY neurons from the NST are specifically activated by RF, whereas those from the ARC are generally stimulated by an increased food demand.
Authors:
Kouji Ishizaki; Sato Honma; Yumiko Katsuno; Hiroshi Abe; Satoru Masubuchi; Masakazu Namihira; Ken-ichi Honma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  17     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-06-05     Completed Date:  2003-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  2097-105     Citation Subset:  IM    
Affiliation:
Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arcuate Nucleus / physiology
Corticosterone / blood
Eating / physiology*
Food Deprivation / physiology*
Gene Expression Regulation / physiology
Male
Neuropeptide Y / genetics*
Paraventricular Hypothalamic Nucleus / physiology
RNA, Messenger / analysis
Rats
Rats, Wistar
Solitary Nucleus / physiology*
Chemical
Reg. No./Substance:
0/Neuropeptide Y; 0/RNA, Messenger; 50-22-6/Corticosterone

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