| Gene expression in lung adenocarcinomas of smokers and nonsmokers. | |
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MedLine Citation:
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PMID: 12600827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adenocarcinoma (AC) has become the most frequent type of lung cancer in men and women, and is the major form of lung cancer in nonsmokers. Our goal in this paper was to determine if AC in smokers and nonsmokers represents the same genetic disease. We compared gene expression profiles in resected samples of nonmalignant lung tissue and tumor tissue in six never-smokers with AC and in six smokers with AC, who were matched for clinical staging and histologic criteria of cell differentiation. Results were analyzed using a variety of bioinformatic tools. Four times as many genes changed expression in the transition from noninvolved lung to tumor in nonsmokers as in smokers, suggesting that AC in nonsmokers evolves locally, whereas AC in smokers evolves in a field of genetically altered tissue. There were some similarities in gene expression in smokers and nonsmokers, but many differences, suggesting different pathways of cell transformation and tumor formation. Gene expression in the noninvolved lungs of smokers differed from that of nonsmokers, and multidimensional scaling showed that noninvolved lungs of smokers groups with tumors rather than noninvolved lungs of nonsmokers. In addition, expression of a number of genes correlated with smoking intensity. Our findings, although limited by small sample size, suggest that additional studies comparing noninvolved to tumor tissue may identify pathogenetic mechanisms and therapeutic targets that differ in AC of smokers and nonsmokers. |
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Authors:
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Charles A Powell; Avrum Spira; Adnan Derti; Charles DeLisi; Gang Liu; Alain Borczuk; Steve Busch; Sudhir Sahasrabudhe; Yangde Chen; David Sugarbaker; Raphael Bueno; William G Richards; Jerome S Brody |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-02-21 |
Journal Detail:
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Title: American journal of respiratory cell and molecular biology Volume: 29 ISSN: 1044-1549 ISO Abbreviation: Am. J. Respir. Cell Mol. Biol. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-24 Completed Date: 2003-09-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8917225 Medline TA: Am J Respir Cell Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 157-62 Citation Subset: IM |
Affiliation:
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Department of Medicine, Columbia College of Physicians and Surgeons, New York, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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etiology,
genetics*,
metabolism* Adult Aged Cell Differentiation Cell Transformation, Neoplastic Computational Biology Female Gene Expression Regulation, Neoplastic* Humans Lung Neoplasms / etiology, genetics*, metabolism* Male Middle Aged Oligonucleotide Array Sequence Analysis Phylogeny Smoking* |
| Comments/Corrections | |
Comment In:
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Am J Respir Cell Mol Biol. 2003 Aug;29(2):153-6
[PMID:
12878582
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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