Document Detail


Gene expression in elongating and gastrulating embryos from ruminants.
MedLine Citation:
PMID:  17491159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In ruminants, more than 30% of the embryonic losses observed after artificial insemination (AI) have an early origin, coincident with a marked elongation of the trophoblast which occurs before implantation. Several observations provide clear evidence that early elongation of the conceptus relies on cell multiplication, cell growth and cell shape remodeling. Recent results indicating an intense multiplication of a non-fully differentiated trophoblast, which still expresses some epiblast genes, has to be considered at the onset of elongation. It has also been shown in the last two years that general metabolism and protein trafficking are characteristic of the onset of elongation whereas cellular interactions, cell to cell signaling and cell adhesion become predominant at the end of elongation. Accordingly, expression of most of the single genes identified so far increases during elongation and is related to the establishment of embryo-maternal exchanges before implantation. However, not much is known of what controls the induction of the elongation process or the coordinated development of the embryonic and extra-embryonic tissues. This review highlights new information on this developmental phase and summarizes the views on the complex cross-talk among molecules which might govern conceptus development and lead to successful implantation.
Authors:
I Hue; S A Degrelle; E Campion; J P Renard
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Society of Reproduction and Fertility supplement     Volume:  64     ISSN:  -     ISO Abbreviation:  Soc Reprod Fertil Suppl     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-11     Completed Date:  2007-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101295315     Medline TA:  Soc Reprod Fertil Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  365-77     Citation Subset:  IM    
Affiliation:
INRA, UMR 1198, ENVA, CNRS, FRE 2857, Biologie du Développement et Reproduction, Jouy en Josas F-78350, France. isabelle.hue@jouy.inra.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Embryonic Development / genetics*
Female
Gastrula / physiology*
Gene Expression
Gene Expression Profiling
Gene Expression Regulation, Developmental*
Microarray Analysis
Pregnancy
Ruminants / physiology*

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