Document Detail

Gene expression changes of urokinase plasminogen activator and urokinase receptor in rat testes at postnatal stages.
MedLine Citation:
PMID:  17712486     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate the gene expression changes of urokinase plasminogen activator (uPA)/urokinase receptor (uPAR) in rat testes at postnatal stages and explore the effects of uPA/uPAR system on the rat spermatogenesis. METHODS: The mRNAs of uPA and uPAR in rat testes were measured by using real-time quantitative polymerase chain reaction (PCR) at postnatal days 0, 5, 10, 15, 21, 28, 35, 42, 49 and 56, respectively. RESULTS: The tendencies of uPA and uPAR mRNA expression were similar at most postnatal stages except for D(0). The expression of uPAR mRNA in rats testes was relatively higher than that of uPA at postnatal D(0), and both were decreased until D(21), increased obviously at postnatal D(28), reached a peak at postnatal D(35), then declined sharply at postnatal D(42) and retained at a low level afterwards. CONCLUSION: The uPA/uPAR system may be strongly linked to spermiation and spermatogenesis via regulating germ cell migration and proliferation, as well as promoting the spermiation and detached residual bodies from the mature spermatids.
Dong-Hui Huang; Hu Zhao; Yong-Hong Tian; Hong-Gang Li; Xiao-Fang Ding; Cheng-Liang Xiong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Asian journal of andrology     Volume:  9     ISSN:  1008-682X     ISO Abbreviation:  Asian J. Androl.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-22     Completed Date:  2007-11-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100942132     Medline TA:  Asian J Androl     Country:  China    
Other Details:
Languages:  eng     Pagination:  679-83     Citation Subset:  IM    
Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
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MeSH Terms
Aging / genetics
Animals, Newborn
Gene Expression Regulation, Developmental*
Gene Expression Regulation, Enzymologic*
Polymerase Chain Reaction
Receptors, Cell Surface / genetics*
Receptors, Urokinase Plasminogen Activator
Spermatozoa / enzymology,  physiology
Testis / growth & development,  physiology*
Urokinase-Type Plasminogen Activator / genetics*
Reg. No./Substance:
0/Plaur protein, rat; 0/Receptors, Cell Surface; 0/Receptors, Urokinase Plasminogen Activator; EC Plasminogen Activator

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