Document Detail

Gene expression changes in human cells after exposure to mobile phone microwaves.
MedLine Citation:
PMID:  16878293     Owner:  NLM     Status:  MEDLINE    
Possible biological effects of mobile phone microwaves were investigated in vitro. In this study, which was part of the 5FP EU project REFLEX (Risk Evaluation of Potential Environmental Hazards From Low-Energy Electromagnetic Field Exposure Using Sensitive in vitro Methods), six human cell types, immortalized cell lines and primary cells, were exposed to 900 and 1800 MHz. RNA was isolated from exposed and sham-exposed cells and labeled for transcriptome analysis on whole-genome cDNA arrays. The results were evaluated statistically using bioinformatics techniques and examined for biological relevance with the help of different databases. NB69 neuroblastoma cells, T lymphocytes, and CHME5 microglial cells did not show significant changes in gene expression. In EA.hy926 endothelial cells, U937 lymphoblastoma cells, and HL-60 leukemia cells we found between 12 and 34 up- or down-regulated genes. Analysis of the affected gene families does not point towards a stress response. However, following microwave exposure, some but not all human cells might react with an increase in expression of genes encoding ribosomal proteins and therefore up-regulating the cellular metabolism.
Daniel Remondini; Reetta Nylund; Jukka Reivinen; Florence Poulletier de Gannes; Bernard Veyret; Isabelle Lagroye; Emmanuelle Haro; M Angeles Trillo; Miriam Capri; Claudio Franceschi; Kathrin Schlatterer; Richard Gminski; Rudolf Fitzner; Rudolf Tauber; Jurgen Schuderer; Niels Kuster; Dariusz Leszczynski; Ferdinando Bersani; Christian Maercker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proteomics     Volume:  6     ISSN:  1615-9853     ISO Abbreviation:  Proteomics     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-04     Completed Date:  2006-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101092707     Medline TA:  Proteomics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  4745-54     Citation Subset:  IM    
University of Bologna, Department of Physics, Bologna, Italy.
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MeSH Terms
Cell Line
Cellular Phone*
Down-Regulation / radiation effects*
Up-Regulation / radiation effects*

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