| Gene expression alteration during redox-dependent enhancement of arsenic cytotoxicity by emodin in HeLa cells. | |
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MedLine Citation:
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PMID: 16045814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Emodin (1,3,8-trihydroxy-6-methylanthraquinone) could enhance the sensitivity of tumor cells to arsenic trioxide (As2O3)-induced apoptosis via generation of ROS, but the molecular mechanism has not been elucidated. Here, we carried out cDNA microarray-based global transcription profiling of HeLa cells in response to As2O3/emodin cotreatment, comparing with As2O3-only treatment. The results showed that the expression of a number of genes was substantially altered at two time points. These genes are involved in different aspects of cell function. In addition to redox regulation and apoptosis, ROS affect genes encoding proteins associated with cell signaling, organelle functions, cell cycle, cytoskeleton, etc. These data suggest that based on the cytotoxicity of As2O3, emodin mobilize every genomic resource through which the As2O3-induced apoptosis is facilitated. |
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Authors:
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Xiao Jing Wang; Jie Yang; Hui Cang; Yan Qiong Zou; Jing Yi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell research Volume: 15 ISSN: 1001-0602 ISO Abbreviation: Cell Res. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-27 Completed Date: 2005-10-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9425763 Medline TA: Cell Res Country: China |
Other Details:
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Languages: eng Pagination: 511-22 Citation Subset: IM |
Affiliation:
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Department of Cell Biology, Shanghai Second Medical University, 280 Chongqing Road, Shanghai 200025, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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drug effects,
physiology Arsenicals Cell Survival / drug effects, physiology Dose-Response Relationship, Drug Emodin / pharmacology* Gene Expression Profiling* Gene Expression Regulation, Neoplastic / drug effects* Hela Cells Humans Microarray Analysis / methods Oxidation-Reduction Oxides / toxicity* RNA, Messenger* / drug effects, genetics Reactive Oxygen Species / metabolism Sensitivity and Specificity Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Arsenicals; 0/Oxides; 0/RNA, Messenger; 0/Reactive Oxygen Species; 1327-53-3/arsenic trioxide; 518-82-1/Emodin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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