Document Detail

Gene expression of NOR-1, a neuron-derived orphan receptor, is inducible in neuronal and other cell lineages in culture.
MedLine Citation:
PMID:  8824899     Owner:  NLM     Status:  MEDLINE    
We recently isolated a cDNA of NOR-1, a novel member of the steroid/thyroid hormone receptor superfamily, from a rat neuronal cell cDNA library. NOR-1 has strong amino acid sequence homology to orphan receptors NGFI-B and Nurr1, and is expressed predominantly in the brain tissue in vivo. In the present study, we examined NOR-1 gene expression in various cultured cells with distinct properties of neuronal cells (PC12), glial cells (C6), endocrine cells (GH3, AtT-20 and Y-1), or fibroblasts (NIH3T3 and L), by reverse transcription-polymerase chain reaction and nucleotide sequencing. NOR-1 transcripts were induced with forskolin and 12-O-tetradecanoylphorbol-13-acetate in all cell lines examined. The nerve growth factor induced not only NGFI-B but also NOR-1 and Nurr1 transcripts in PC12 cells. These findings suggest that NOR-1 gene expression is induced by various stimuli in diverse cell types.
S Bandoh; T Tsukada; K Maruyama; N Ohkura; K Yamaguchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  115     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-12-11     Completed Date:  1996-12-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  227-30     Citation Subset:  IM    
Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan.
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MeSH Terms
3T3 Cells
Cell Line
DNA-Binding Proteins / genetics*
Forskolin / pharmacology*
Gene Expression Regulation / drug effects,  genetics*
L Cells (Cell Line)
Nerve Tissue Proteins / genetics*
Neurons / cytology
PC12 Cells
Receptors, Steroid / genetics*
Receptors, Thyroid Hormone
Tumor Cells, Cultured
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Nerve Tissue Proteins; 0/Nr4a3 protein, mouse; 0/Nr4a3 protein, rat; 0/Receptors, Steroid; 0/Receptors, Thyroid Hormone; 66428-89-5/Forskolin

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