Document Detail

Gene evolution in the chicken beta-globin cluster.
MedLine Citation:
PMID:  6896168     Owner:  NLM     Status:  MEDLINE    
We have determined the cDNA sequence of the chicken embryonic beta-like epsilon-globin gene. Comparison with the sequences of the chicken rho-globin and beta-globin genes reveals the presence of two regions that are identical or nearly identical in epsilon and rho. The first contains the 5' untranslated sequence and exon 1, while the second region includes the second half of exon 2. Outside these regions rho and epsilon are less homologous to each other than to the adult beta-globin gene. The embryonic rho and epsilon genes are located at opposite ends of the beta-globin-gene cluster, not contiguously as are all other known pairs of simultaneously expressed globin genes. We suggest a role for gene conversion in the synchronization of expression of two highly diverged genes.
I B Roninson; V M Ingram
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell     Volume:  28     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-07-08     Completed Date:  1982-07-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  515-21     Citation Subset:  IM    
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MeSH Terms
Base Sequence
Chick Embryo
Chickens / genetics*
DNA / analysis
DNA, Recombinant
Erythrocytes / physiology
Genetic Variation
Globins / genetics*
Reg. No./Substance:
0/DNA, Recombinant; 9004-22-2/Globins; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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