Document Detail


Gene-environment interplay in Drosophila melanogaster: chronic food deprivation in early life affects adult exploratory and fitness traits.
MedLine Citation:
PMID:  23045644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Early life adversity has known impacts on adult health and behavior, yet little is known about the gene-environment interactions (GEIs) that underlie these consequences. We used the fruit fly Drosophila melanogaster to show that chronic early nutritional adversity interacts with rover and sitter allelic variants of foraging (for) to affect adult exploratory behavior, a phenotype that is critical for foraging, and reproductive fitness. Chronic nutritional adversity during adulthood did not affect rover or sitter adult exploratory behavior; however, early nutritional adversity in the larval period increased sitter but not rover adult exploratory behavior. Increasing for gene expression in the mushroom bodies, an important center of integration in the fly brain, changed the amount of exploratory behavior exhibited by sitter adults when they did not experience early nutritional adversity but had no effect in sitters that experienced early nutritional adversity. Manipulation of the larval nutritional environment also affected adult reproductive output of sitters but not rovers, indicating GEIs on fitness itself. The natural for variants are an excellent model to examine how GEIs underlie the biological embedding of early experience.
Authors:
James Geoffrey Burns; Nicolas Svetec; Locke Rowe; Frederic Mery; Michael J Dolan; W Thomas Boyce; Marla B Sokolowski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-08
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109 Suppl 2     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-17     Completed Date:  2013-01-16     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17239-44     Citation Subset:  IM    
Affiliation:
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / physiology*
Drosophila melanogaster / genetics*,  growth & development,  physiology*
Exploratory Behavior
Female
Fertility / genetics,  physiology
Food Deprivation
Gene-Environment Interaction
Genes, Insect
Genetic Fitness / genetics,  physiology
Male
Grant Support
ID/Acronym/Agency:
//Canadian Institutes of Health Research
Comments/Corrections

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