Document Detail

Gene-environment interaction and the genetics of depression.
MedLine Citation:
PMID:  15173894     Owner:  NLM     Status:  MEDLINE    
Depression is a group of brain disorders with varied origins, complex genetics and obscure neurobiology. Definitions of clinical phenotypes are not rooted in their neurobiology, and animal models of behavioural despair have considerable limitations. Nevertheless, investigation of subtle alterations in gene expression, of correlations between genotype and brain activity, and of environmental variables interacting with genetic variants have advanced research into the genetics of depression. Although the postgenomic era is still in its infancy, several milestones have already been reached: variation in gene expression has been confirmed to play a predominant role in individual differences; gene-environment interactions have been established in humans and in a nonhuman primate model; gene-phenotype correlations have been substantiated by functional neuroimaging; and the notion of gene networks that control brain development is increasingly recognized. Given the etiologic and psychobiologic complexity of mood disorders, it is not surprising that the identification of specific genetic factors is extremely difficult and continues to be among the last frontiers of gene hunting.
Klaus Peter Lesch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of psychiatry & neuroscience : JPN     Volume:  29     ISSN:  1180-4882     ISO Abbreviation:  J Psychiatry Neurosci     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-06-02     Completed Date:  2004-07-22     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  9107859     Medline TA:  J Psychiatry Neurosci     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  174-84     Citation Subset:  IM    
Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany.
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MeSH Terms
Depressive Disorder, Major / genetics*
Genetic Linkage / genetics

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