Document Detail


Gene-environment interaction between dopamine receptor D4 7-repeat polymorphism and early maternal sensitivity predicts inattention trajectories across middle childhood.
MedLine Citation:
PMID:  23627945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Evidence suggests that the 7-repeat variant of a 48 base pair variable number tandem repeat polymorphism in the dopamine receptor D4 (DRD4) gene may be associated with the development of attention problems. A parallel literature suggests that genes linked to dopaminergic functioning may be associated with differential sensitivity to context, such that the direction of the genetic effect is hypothesized to vary across environmental experience. Guided by these literatures, we used data from the NICHD Study of Early Child Care and Youth Development to consider (a) whether individual differences in children's inattention problems across middle childhood are predicted by gene-environment interactions between the DRD4 gene 7-repeat polymorphism and children's experiences of maternal sensitivity across infancy and early childhood and (b) the degree to which such interactions are consistent with the differential-sensitivity model. Largely consistent with the hypothesized model, gene-environment interactions indicated that, in the context of insensitive early maternal care, the DRD4 7-repeat polymorphism was associated with higher levels of inattention. Although somewhat less consistently, there was also evidence that, in the context of highly sensitive care, the 7-repeat polymorphism was associated with lower levels of inattention. Overall, the magnitude of the absolute genetic effect increased over time, as children's inattention trajectories diverged.
Authors:
Daniel Berry; Kirby Deater-Deckard; Kathleen McCartney; Zhe Wang; Stephen A Petrill
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development and psychopathology     Volume:  25     ISSN:  1469-2198     ISO Abbreviation:  Dev. Psychopathol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-30     Completed Date:  2013-12-17     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  8910645     Medline TA:  Dev Psychopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  291-306     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alleles
Attention / physiology*
Attention Deficit Disorder with Hyperactivity / etiology*,  genetics,  psychology
Child
Child, Preschool
Female
Gene-Environment Interaction
Genotype
Humans
Infant
Longitudinal Studies
Male
Maternal Behavior / physiology*
Mother-Child Relations*
Polymorphism, Genetic
Receptors, Dopamine D4 / genetics*
Tandem Repeat Sequences
Grant Support
ID/Acronym/Agency:
5R01HD051502/HD/NICHD NIH HHS; HD25451/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/DRD4 protein, human; 137750-34-6/Receptors, Dopamine D4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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