Document Detail

Gene duplications as a recurrent theme in the evolution of the human pseudoautosomal region 1: isolation of the gene ASMTL.
MedLine Citation:
PMID:  9736779     Owner:  NLM     Status:  MEDLINE    
We have isolated a novel gene, ASMTL (acetylserotonin methytransferase-like ), in the pseudoautosomal region (PAR1) on the human sex chromosomes. ASMTL represents a unique fusion product of two different full-length genes of different evolutionary origin and function. One part is homologous to the bacterial maf/orfE genes. The other part shows significant homology to the entire open reading frame of the previously described pseudoautosomal gene ASMT, encoding the enzyme catalysing the last step in the synthesis of melatonin. We have also detected the identity of one exon (1A) of ASMT to exon 3 in yet another pseudoautosomal gene, XE7. The data presented suggest that exon duplication and exon shuffling as well as gene fusion may represent common characteristics in the pseudoautosomal region.
K Ried; E Rao; K Schiebel; G A Rappold
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human molecular genetics     Volume:  7     ISSN:  0964-6906     ISO Abbreviation:  Hum. Mol. Genet.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-12-01     Completed Date:  1998-12-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9208958     Medline TA:  Hum Mol Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1771-8     Citation Subset:  IM    
Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany.
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MeSH Terms
Acetylserotonin O-Methyltransferase / genetics*
Amino Acid Sequence
Artificial Gene Fusion
Chromosome Mapping / methods
Cloning, Molecular
Evolution, Molecular*
Gene Duplication*
Methyltransferases / genetics*,  metabolism
Molecular Sequence Data
Sequence Homology, Amino Acid
Sex Chromosomes
Tissue Distribution
X Chromosome
Reg. No./Substance:
EC 2.1.1.-/ASMTL protein, human; EC 2.1.1.-/Methyltransferases; EC O-Methyltransferase

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