Document Detail


Gene dose effect of the APOE-epsilon4 allele on plasma HDL cholesterol level in patients with Alzheimer's disease.
MedLine Citation:
PMID:  11755017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been reported that decreased serum high density lipoprotein (HDL) cholesterol level is related with severity of Alzheimer's disease (AD). Here, 82 patients with AD and 40 non-demented individuals were examined to determine how the APOE-epsilon4 allele modifies plasma cholesterol fractions. In adjusting for age, sex and plasma albumin level, plasma HDL cholesterol level was inversely correlated with the APOE-epsilon4 dose only in the patients (P = 0.0048), while plasma low density lipoprotein (LDL) cholesterol level tended to be correlated with the APOE-epsilon4 dose in both groups, although this was not significant. The ratio of LDL to HDL cholesterol in the patients showed a similar correlation with the APOE-epsilon4 dose to that in the controls, and this correlation was evident (P = 0.0069) after putting all subjects into one group. However, neither HDL nor LDL cholesterol levels showed significant differences between the groups. These results indicated that the APOE-epsilon4 dose affects the composition of plasma cholesterol, and suggested that the genetic effect on plasma lipid metabolism could be distinctive in patients with AD.
Authors:
Tomoko Hoshino; Kouzin Kamino; Masayuki Matsumoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurobiology of aging     Volume:  23     ISSN:  0197-4580     ISO Abbreviation:  Neurobiol. Aging     Publication Date:    2002 Jan-Feb
Date Detail:
Created Date:  2001-12-28     Completed Date:  2002-02-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
Affiliation:
Department of Geriatric Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-cho, Kahoku-gun, 920-0293, Ishikawa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging / genetics,  physiology*
Alleles
Alzheimer Disease / blood*
Apolipoprotein E4
Apolipoproteins E / genetics*
Cholesterol, HDL / blood*
Cholesterol, LDL / blood
Female
Gene Dosage*
Genotype
Humans
Lipids / blood
Male
Nutritional Physiological Phenomena
Regression Analysis
Serum Albumin / metabolism
Chemical
Reg. No./Substance:
0/Apolipoprotein E4; 0/Apolipoproteins E; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 0/Serum Albumin

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