| Gene delivery with viral vectors for cerebrovascular diseases . | |
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MedLine Citation:
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PMID: 23276981 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Recent achievements in the understanding of molecular events involved in the pathogenesis of central nervous system (CNS) injury have made gene transfer a promising approach for various neurological disorders, including cerebrovascular diseases. However, special obstacles, including the post-mitotic nature of neurons and the blood-brain barrier (BBB), constitute key challenges for gene delivery to the CNS. Despite the various limitations in current gene delivery systems, a spectrum of viral vectors has been successfully used to deliver genes to the CNS. Furthermore, recent advancements in vector engineering have improved the safety and delivery of viral vectors. Numerous viral vector-based clinical trials for neurological disorders have been initiated. This review will summarize the current implementation of viral gene delivery in the context of cerebrovascular diseases including ischemic stroke, hemorrhagic stroke and subarachnoid hemorrhage (SAH). In particular, we will discuss the potentially feasible ways in which viral vectors can be manipulated and exploited for use in neural delivery and therapy. |
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Authors:
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Yu Gan; Zheng Jing; Ruth Anne Stetler; Guodong Cao |
Publication Detail:
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Type: Journal Article Date: 2013-01-01 |
Journal Detail:
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Title: Frontiers in bioscience (Elite edition) Volume: 5 ISSN: 1945-0508 ISO Abbreviation: Front Biosci (Elite Ed) Publication Date: 2013 |
Date Detail:
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Created Date: 2013-01-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485240 Medline TA: Front Biosci (Elite Ed) Country: United States |
Other Details:
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Languages: eng Pagination: 188-203 Citation Subset: IM |
Affiliation:
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Department of Neurology, S505 BST, University of Pittsburgh, School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15261. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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