| Gene delivery to the retina: from mouse to man. | |
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MedLine Citation:
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PMID: 22365778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With the recent progress in identifying disease-causing genes in humans and in animal models, there are more and more opportunities for using retinal gene transfer to learn more about retinal physiology and also to develop therapies for blinding disorders. Success in preclinical studies for one form of inherited blindness have led to testing in human clinical trials. This paves the way to consider a number of other retinal diseases as ultimate gene therapy targets in human studies. The information presented here is designed to assist scientists and clinicians to use gene transfer to probe the biology of the retina and/or to move appropriate gene-based treatment studies from the bench to the clinic. |
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Authors:
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Jean Bennett; Daniel C Chung; Albert Maguire |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Methods in enzymology Volume: 507 ISSN: 1557-7988 ISO Abbreviation: Meth. Enzymol. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-02-27 Completed Date: 2012-06-11 Revised Date: 2013-06-06 |
Medline Journal Info:
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Nlm Unique ID: 0212271 Medline TA: Methods Enzymol Country: United States |
Other Details:
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Languages: eng Pagination: 255-74 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Gene Transfer Techniques* Genetic Therapy / methods* Humans Injections, Intraocular / methods* Mice Primates Retina / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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1DP1OD008267-01/OD/NIH HHS; 1R24EY019861-01A1/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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