Document Detail


Gene conversion in the evolution of both the H-2 and Qa class I genes of the murine major histocompatibility complex.
MedLine Citation:
PMID:  2076814     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to better understand the role of gene conversion in the evolution of the class I gene family of the major histocompatibility complex (MHC), we have used a computer algorithm to detect clustered sequence similarities among 24 class I DNA sequences from the H-2, Qa, and Tla regions of the murine MHC. Thirty-four statistically significant clusters were detected; individual analysis of the clusters suggested at least 25 past gene conversion or recombination events. These clusters are comparable in size to the conversions observed in the spontaneously occurring H-2Kbm and H-2Kkm2 mutations, and are distributed throughout all exons of the class I gene. Thus, gene conversion does not appear to be restricted to the regions of the class I gene encoding their antigen-presentation function. Moreover, both the highly polymorphic H-2 loci and the relatively monomorphic Qa and Tla loci appear to have participated as donors and recipients in conversion events. If gene conversion is not limited to the highly polymorphic loci of the MHC, then another factor, presumably natural selection, must be responsible for maintaining the observed differences in level of variation.
Authors:
M Kuhner; S Watts; W Klitz; G Thomson; R S Goodenow
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genetics     Volume:  126     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-04-25     Completed Date:  1991-04-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1115-26     Citation Subset:  IM    
Affiliation:
Department of Integrative Biology, University of California, Berkeley 94720.
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Base Sequence
Cattle
Evolution*
Gene Conversion*
Genes, MHC Class I*
Humans
Mice
Sequence Homology, Nucleic Acid
Grant Support
ID/Acronym/Agency:
CA37099/CA/NCI NIH HHS; GM07232-10/GM/NIGMS NIH HHS; GM35326/GM/NIGMS NIH HHS
Comments/Corrections

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