Document Detail


Gene assignment of alpha-fucosidase and glucose dehydrogenase to the p21 leads to pter region of chromosome 1 in man.
MedLine Citation:
PMID:  567853     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Assignment of human genes coding for alpha-fucosidase (alphaFUC) and glucose dehydrogenase (GDH) to chromosome 1 has been confirmed and a location in the p21 leads to pter region demonstrated using man-mouse somatic cell hybrids. The regional location of alphaFUC and GDH was established in cell hybrids using human cells possessing 1/2 translocation chromosomes [46,XX,t(1;2)(p21;q37)]. Hybrids which retained the 2q+ chromosome carrying the 1p21 leads to 1pter region concordantly expressed alphaFUC, GDH, and the short-arm markers ENO1, AK2, and PGM1. Hybrids which retained the 1p21 leads to 1qter region only expressed human PEPC and FH. Data obtained from hybrids in which spontaneous breaks in chromosome 1 had occurred indicate that the gene order in 1p21 leads to 1pter is (ENO1,GDH)-alphaFUC-AK2-PGM1.
Authors:
G A Koch; J A Brown; T B Shows
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Somatic cell genetics     Volume:  4     ISSN:  0098-0366     ISO Abbreviation:  Somatic Cell Genet.     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-11-18     Completed Date:  1978-11-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506054     Medline TA:  Somatic Cell Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  313-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbohydrate Dehydrogenases / genetics*
Chromosome Mapping
Chromosomes, Human, 1-3*
Genes*
Glucose Dehydrogenases / genetics*
Humans
Hybrid Cells / enzymology
Mice
alpha-L-Fucosidase / genetics*
Chemical
Reg. No./Substance:
EC 1.1.-/Carbohydrate Dehydrogenases; EC 1.1.1.-/Glucose Dehydrogenases; EC 3.2.1.51/alpha-L-Fucosidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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