Document Detail


Gene profiling reveals a role for stress hormones in the molecular and behavioral response to food restriction.
MedLine Citation:
PMID:  21855858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Food restriction is known to enhance learning and motivation. The neural mechanisms underlying these responses likely involve alterations in gene expression in brain regions mediating the motivation to feed.
METHODS: Analysis of gene expression profiles in male C57BL/6J mice using whole-genome microarrays was completed in the medial prefrontal cortex, nucleus accumbens, ventral tegmental area, and the hypothalamus following a 5-day food restriction. Quantitative polymerase chain reaction was used to validate these findings and determine the time course of expression changes. Plasma levels of the stress hormone corticosterone (CORT) were measured by enzyme-linked immunosorbent assay. Expression changes were measured in adrenalectomized animals that underwent food restriction, as well as in animals receiving daily injections of CORT. Progressive ratio responding for food, a measure of motivated behavior, was assessed after CORT treatment in restricted and fed animals.
RESULTS: Brief food restriction results in an upregulation of peripheral stress responsive genes in the mammalian brain. Time-course analysis demonstrated rapid and persistent expression changes in all four brain regions under study. Administration of CORT to nonrestricted animals was sufficient to induce a subset of the genes, and alterations in gene expression after food restriction were dependent on intact adrenal glands. CORT can increase the motivation to work for food only in the restricted state.
CONCLUSIONS: These data demonstrate a central role for CORT in mediating both molecular and behavioral responses to food restriction. The stress hormone-induced alterations in gene expression described here may be relevant for both adaptive and pathological responses to stress.
Authors:
Douglas J Guarnieri; Catherine E Brayton; Sarah M Richards; Jaime Maldonado-Aviles; Joseph R Trinko; Jessica Nelson; Jane R Taylor; Shannon L Gourley; Ralph J DiLeone
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological psychiatry     Volume:  71     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-23     Completed Date:  2012-06-12     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  358-65     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / metabolism,  surgery
Adrenalectomy / psychology
Adrenocorticotropic Hormone / antagonists & inhibitors,  metabolism
Animals
Behavior, Animal
Brain / metabolism
Corticosterone* / administration & dosage,  metabolism
Enzyme-Linked Immunosorbent Assay
Gene Expression Profiling*
Genome-Wide Association Study
Glucocorticoids / administration & dosage,  metabolism
Learning / drug effects*
Male
Mice
Mice, Inbred C57BL
Motivation / drug effects*
Neuronal Plasticity / genetics
Starvation* / genetics,  metabolism,  psychology
Grant Support
ID/Acronym/Agency:
R01 DA011717/DA/NIDA NIH HHS; R01 DA015222/DA/NIDA NIH HHS; R01 DK076964/DK/NIDDK NIH HHS; RL1 AA017537/AA/NIAAA NIH HHS; RL1 AA017537-01/AA/NIAAA NIH HHS; RL1AA017537/AA/NIAAA NIH HHS; UL-DE19586/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Glucocorticoids; 9002-60-2/Adrenocorticotropic Hormone; W980KJ009P/Corticosterone
Comments/Corrections

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