Document Detail


Gene expression in the ventral tegmental area of 5 pairs of rat lines selectively bred for high or low ethanol consumption.
MedLine Citation:
PMID:  22579914     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to determine if there are common innate differences in gene expression or gene pathways in the ventral tegmental area (VTA) among 5 different pairs of rat lines selectively bred for high (HEC) or low (LEC) ethanol consumption: (a) alcohol-preferring (P) vs. alcohol-non-preferring (NP) rats; (b) high-alcohol-drinking (HAD) vs. low-alcohol-drinking (LAD) rats (replicate line pairs 1 and 2); (c) ALKO alcohol (AA) vs. nonalcohol (ANA) rats; and (d) Sardinian alcohol-preferring (sP) vs. alcohol-nonpreferring (sNP) rats. Microarray analysis revealed between 370 and 1340 unique named genes that significantly differed in expression between the individual line-pairs. Analysis using Gene Ontology (GO) and Ingenuity Pathways information indicated significant categories and networks in common for up to 3 line-pairs, but not for all 5 line-pairs; moreover, there were few genes in common in these categories and networks. ANOVA of the combined data for the 5 line-pairs indicated 1295 significant (p<0.01) differences in expression of named genes. Although no individual named gene was significant across all 5 line-pairs, there were 22 genes that overlapped in the same direction in 3 or 4 of the line-pairs. Overall, the findings suggest that (a) some biological categories or networks may be in common for subsets of line-pairs; and (b) regulation of different genes and/or combinations of multiple biological systems (e.g., transcription, synaptic function, intracellular signaling and protection against oxidative stress) within the VTA (possibly involving dopamine and glutamate) may be contributing to the disparate alcohol drinking behaviors of these line-pairs.
Authors:
William J McBride; Mark W Kimpel; Jeanette N McClintick; Zheng-Ming Ding; Petri Hyytia; Giancarlo Colombo; Howard J Edenberg; Lawrence Lumeng; Richard L Bell
Related Documents :
11686874 - Modifier genes and variation in cystic fibrosis.
21953874 - Two pathways for pyrrole formation in coumermycin a(1) biosynthesis: the central pyrrol...
14578194 - Non-small-cell lung cancer molecular signatures recapitulate lung developmental pathways.
12485814 - Myocardial fibrosis blunts nitric oxide synthase-related preload reserve in human dilat...
17200664 - Gene expression profile of the adult human retinal ganglion cell layer.
15598834 - Ls bound based gene selection for dna microarray data.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-05-10
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  102     ISSN:  1873-5177     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-06-25     Completed Date:  2012-11-19     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  275-85     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Ethanol / administration & dosage*
Gene Expression Profiling*
Oligonucleotide Array Sequence Analysis
Rats
Grant Support
ID/Acronym/Agency:
AA013522/AA/NIAAA NIH HHS; AA016652/AA/NIAAA NIH HHS; AA016660/AA/NIAAA NIH HHS; AA07611/AA/NIAAA NIH HHS; P60 AA007611/AA/NIAAA NIH HHS; R24 AA015512/AA/NIAAA NIH HHS; U01 AA013522/AA/NIAAA NIH HHS; U01 AA016652/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
3K9958V90M/Ethanol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice.
Next Document:  ?(2) - Adrenoceptor and insulin receptor expression in the skeletal muscle of streptozotocin induced...